ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Synaptic activation and membrane potential changes modulate the frequency of spontaneous elementary Ca2+ release events in the dendrites of pyramidal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
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- Endoplasmic Reticulum Calcium Signaling in Hippocampal Neurons.Biomolecules · 2024Review
- Luminal transport through intact endoplasmic reticulum limits the magnitude of localized CaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Endoplasmic Reticulum-Plasma Membrane Junctions as Sites of Depolarization-Induced CaAnnual review of physiology · 2023Review
- Neuronal microRNAs safeguard ER CaCellular and molecular life sciences : CMLS · 2022Article
- Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory.Communications biology · 2022Article
- Ion Channel Partnerships: Odd and Not-So-Odd Couples Controlling Neuronal Ion Channel Function.International journal of molecular sciences · 2022Review
- The spatio-temporal properties of calcium transients in hippocampal pyramidal neuronsFrontiers in cellular neuroscience · 2022Article
- Mutations in DISC1 alter IPNeuronal signaling · 2021Review
- Ca2+ transients in melanocyte dendrites and dendritic spine-like structures evoked by cell-to-cell signaling.The Journal of cell biology · 2020Article
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- Ryanodine receptor cluster size sets the tone in cerebral smooth muscle.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors.Cell reports · 2018Article
- Ethanol-Induced Alterations in Purkinje Neuron Dendrites in Adult and Aging Rats: a Review.Cerebellum (London, England) · 2015Article
- Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics.PLoS biology · 2015Article
- Imaging with organic indicators and high-speed charge-coupled device cameras in neurons: some applications where these classic techniques have advantages.Neurophotonics · 2015Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In most neurons postsynaptic [Ca(2+)](i) changes result from synaptic activation opening voltage gated channels, ligand gated channels, or mobilizing Ca(2+) release from intracellular stores. In addition to these changes that result directly from stimulation we found that in pyramidal cells there are spontaneous, rapid, Ca(2+) release events, predominantly, but not exclusively localized at dendritic branch points. They are clearest on the main apical dendrite but also have been detected in the finer branches and in the soma. Typically they have a spatial extent at initiation of approximately 2 microm, a rise time of <15 ms, duration <100 ms, and amplitudes of 10-70% of that generated by a backpropagating action potential at the same location. These events are not caused by background electrical or synaptic activity. However, their rate can be increased by repetitive synaptic stimulation at moderate frequencies, mainly through metabotropic glutamate receptor mobilization of IP(3). In addition, their frequency can be modulated by changes in membrane potential in the subthreshold range, predominantly by affecting Ca(2+) entry through L-type channels. They resemble the elementary events ("sparks" and "puffs") mediated by IP(3) receptors and ryanodine receptors that have been described primarily in non-neuronal preparations. These spontaneous Ca(2+) release events may be the fundamental units underlying some postsynaptic signaling cascades in mature neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.