ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Two R7 regulator of G-protein signaling proteins shape retinal bipolar cell signaling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- Arginyltransferase (Ate1) regulates the RGS7 protein level and the sensitivity of light-evoked ON-bipolar responses.Scientific reports · 2021Article
- Endogenous Opioid Signaling in the Mouse Retina Modulates Pupillary Light Reflex.International journal of molecular sciences · 2021Article
- Arginylation Regulates G-protein Signaling in the Retina.Frontiers in cell and developmental biology · 2021Article
- Cone synapses in mammalian retinal rod bipolar cells.The Journal of comparative neurology · 2018Article
- Differential epitope masking reveals synapse-specific complexes of TRPM1.Visual neuroscience · 2018Article
- The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.Annual review of vision science · 2017Review
- Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.The Journal of clinical investigation · 2015Article
- Article
- Differential function of Gγ13 in rod bipolar and ON cone bipolar cells.The Journal of physiology · 2015Article
- RGS Protein Regulation of Phototransduction.Progress in molecular biology and translational science · 2015Review
- G protein signaling in the retina and beyond: the Cogan lecture.Investigative ophthalmology & visual science · 2014Article
- Oligomeric state of purified transient receptor potential melastatin-1 (TRPM1), a protein essential for dim light vision.The Journal of biological chemistry · 2014Article
- Mouse b-wave mutants.Documenta ophthalmologica. Advances in ophthalmology · 2014Review
- Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons.Investigative ophthalmology & visual science · 2013Article
- An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina.PloS one · 2013Article
- The relationship between slow photoresponse recovery rate and temporal resolution of vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- "mGlu Receptors in the Retina" - WIREs Membrane Transport and Signaling.Wiley interdisciplinary reviews. Membrane transport and signaling · 2012Article
- Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells.Journal of neurochemistry · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
RGS7, RGS11, and their binding partner Gbeta5 are localized to the dendritic tips of retinal ON bipolar cells (ON-BPC), where mGluR6 responds to glutamate released from photoreceptor terminals by activation of the RGS7/RGS11 substrate, Galphao. To determine their functions in retinal signaling, we investigated cell-specific expression patterns of RGS7 and RGS11 by immunostaining, and measured light responses by electroretinography in mice with targeted disruptions of the genes encoding them. RGS7 staining is present in dendritic tips of all rod ON-BPC, but missing in those for subsets of cone ON-BPC, whereas the converse was true for RGS11 staining. Genetic disruption of either RGS7 or RGS11 produced delays in the ON-BPC-derived electroretinogram b-wave, but no changes in the photoreceptor-derived a-wave. Homozygous RGS7 mutant mice had delays in rod-driven b-waves, whereas RGS11 mutant mice had delays in rod-driven, and especially in cone-driven b-waves. The b-wave delays were further enhanced in mice homozygous for both RGS7 and RGS11 gene disruptions. Thus, RGS7 and RGS11 act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.