ArticleAmerican journal of physiology. Renal physiology2009
The long-term label retaining population of the renal papilla arises through divergent regional growth of the kidney.
Article in American journal of physiology. Renal physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Regenerative Versus Nonregenerative Repair of the Renal Medulla After Reversal of Ureteral Obstruction.Seminars in nephrology · 2025Review
- Developmental and Cell Fate Analyses Support a Postnatal Origin for the Cortical Collecting System in the Mouse Kidney.Journal of the American Society of Nephrology : JASN · 2025Article
- Determining lineage relationships in kidney development and disease.Nature reviews. Nephrology · 2022Review
- Kidney Cells Regeneration: Dedifferentiation of Tubular Epithelium, Resident Stem Cells and Possible Niches for Renal Progenitors.International journal of molecular sciences · 2019Review
- Reduced Abd-B Hox function during kidney development results in lineage infidelity.Developmental biology · 2018Article
- Cellular plasticity in kidney injury and repair.Nature reviews. Nephrology · 2017Review
- LGR4 is required for sequential molar development.Biochemistry and biophysics reports · 2016Article
- The role of long-term label-retaining cells in the regeneration of adult mouse kidney after ischemia/reperfusion injury.Stem cell research & therapy · 2016Article
- Each niche has an actor: multiple stem cell niches in the preterm kidney.Italian journal of pediatrics · 2015Review
- Article
- Distinct populations of label-retaining cells in the adult kidney are defined temporally and exhibit divergent regional distributions.American journal of physiology. Renal physiology · 2014Article
- The bigger the better: determining nephron size in kidney.Pediatric nephrology (Berlin, Germany) · 2014Review
- Label-retaining cells in the adult murine salivary glands possess characteristics of adult progenitor cells.PloS one · 2014Article
- Stromal cells in tissue homeostasis: balancing regeneration and fibrosis.Nature reviews. Nephrology · 2013Review
- Generation and characterization of KsprtTA and KsptTA transgenic mice.Genesis (New York, N.Y. : 2000) · 2013Article
- Regenerative medicine for the kidney: stem cell prospects & challenges.Clinical and translational medicine · 2013Article
- Characterization and fate of telomerase-expressing epithelia during kidney repair.Journal of the American Society of Nephrology : JASN · 2011Article
- Repair of injured proximal tubule does not involve specialized progenitors.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Development of the kidney medulla.OrganogenesisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Long-term pulse chase experiments previously identified a sizable population of BrdU-retaining cells within the renal papilla. The origin of these cells has been unclear, and in this work we test the hypothesis that they become quiescent early during the course of kidney development and organ growth. Indeed, we find that BrdU-retaining cells of the papilla can be labeled only by pulsing with BrdU from embryonic (E) day 11.25 to postnatal (P) day 7, the approximate period of kidney development in the mouse. BrdU signal in the cortex and outer medulla is rapidly diluted by cellular proliferation during embryonic development and juvenile growth, whereas cells within the papilla differentiate and exit the cell cycle during organogenesis. Indeed, by E17.5, little or no active proliferation can be seen in the distal papilla, indicating maturation of this structure in a distal-to-proximal manner during organogenesis. We conclude that BrdU-retaining cells of the papilla represent a population of cells that quiesce during embryonic development and localize within a region of the kidney that matures early. We therefore propose that selective papillary retention of BrdU arises through a combination of regionalized slowing of, and exit from, the cell cycle within the papilla during the period of ongoing kidney development, and extensive proliferative growth of the juvenile kidney resulting in dilution of BrdU below the detection level in extra-papillary regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.