ArticleBMJ (Clinical research ed.)2009
Factors associated with mortality in Scottish patients receiving methadone in primary care: retrospective cohort study.
Article in BMJ (Clinical research ed.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04622995 (Exploring the Utility and Safety of Benzodiazepine Prescribing Among People Receiving Opiate Replacement Therapy in Scotland), which is not on this map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploring the Utility and Safety of Benzodiazepine Prescribing Among People Receiving Opiate Replacement Therapy in Scotland (the BENZORT Study).
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The association between benzodiazepine co-prescription, opioid agonist treatment and mortality: a systematic review.BMC psychiatry · 2024Pooled it
- Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis.Molecular psychiatry · 2019Pooled it
- Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies.BMJ (Clinical research ed.) · 2017Pooled it
- Study protocol of the ESUB-MG cluster randomized trial: a pragmatic trial assessing the implementation of urine drug screening in general practice for buprenorphine maintained patients.BMC family practice · 2016Trial
- Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville).PloS one · 2014Trial
- "It could potentially be dangerous... but nothing else has seemed to help me.": Patient and clinician perspectives on benzodiazepine use in opioid agonist treatment.Journal of substance abuse treatment · 2021Article
- Mechanisms and context in the San Patrignano drug recovery community, Italy: a qualitative study to inform transfer to Scotland.Drugs (Abingdon, England) · 2021Article
- Do interruptions to the continuity of methadone maintenance treatment in specialist addiction settings increase the risk of drug-related poisoning deaths? A retrospective cohort study.Addiction (Abingdon, England) · 2020Observational
- COVID-19 and the health of people who use drugs: What is and what could be?The International journal on drug policy · 2020Article
- Baseline Factors Associated with Mortality in Patients Who Engaged in Buprenorphine Treatment for Opioid Use Disorder: a Cohort Study.Journal of general internal medicine · 2020Article
- Correlates of death during outpatient treatment for opioid use disorder: A national study.Journal of substance abuse treatment · 2020Article
- Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study.BMJ (Clinical research ed.) · 2020Article
- Observational
- Mortality and causes of death among patients with opioid use disorder receiving opioid agonist treatment: a national register study.BMC health services research · 2019Observational
- The impact of buprenorphine and methadone on mortality: a primary care cohort study in the United Kingdom.Addiction (Abingdon, England) · 2018Article
- Increasing availability of benzodiazepines among people who inject drugs in a Canadian setting.Substance abuse · 2018Article
- Supervised Injectable Heroin: A Clinical Perspective.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Review
- Overall Survival among Cancer Patients Undergoing Opioid Rotation to Methadone Compared to Other Opioids.Journal of palliative medicine · 2017Article
- Article
- National Action Plan for Adverse Drug Event Prevention: Recommendations for Safer Outpatient Opioid Use.Pain medicine (Malden, Mass.) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveTo assess predictors of mortality in a population of people prescribed methadone.
designRetrospective cohort study.
settingGeographically defined population in Tayside, Scotland.
participants2378 people prescribed and dispensed liquid methadone between January 1993 and February 2004.
main outcome measuresAll cause mortality (primary outcome) and drug dependent cause specific mortality (secondary outcome) by means of Cox proportional hazards models during 12 years of follow-up.
resultsOverall, 181 (8%) people died. Overuse of methadone (adjusted hazard ratio 1.67, 95% confidence interval 1.05 to 2.67), history of psychiatric admission (2.47, 1.67 to 3.66), and increasing comorbidity measured as Charlson index >or=3 (1.20, 1.15 to 1.26) were all associated with an increase in all cause mortality. Longer duration of use (adjusted hazard ratio 0.95, 0.94 to 0.96), history of having urine tested (0.33, 0.22 to 0.49), and increasing time since last filled prescription were protective in relation to all cause mortality. Drug dependence was identified as the principal cause of death in 60 (33%) people. History of psychiatric admission was significantly associated with drug dependent death (adjusted hazard ratio 2.41, 1.25 to 4.64), as was history of prescription of benzodiazepines (4.35, 1.32 to 14.30).
conclusionsImportant elements of care in provision of methadone maintenance treatment are likely to influence, or be a marker for, a person's risk of death.
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Registered trials
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