ArticleVirology2009
Zoonotic potential of highly pathogenic avian H7N3 influenza viruses from Pakistan.
Article in Virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular Evolution of the H5 and H7 Highly Pathogenic Avian Influenza Virus Haemagglutinin Cleavage Site Motif.Reviews in medical virology · 2025Review
- Influenza A virus infection and pathology in nasal and periocular tissues after ocular inoculation in ferrets.Veterinary pathology · 2022Article
- Article
- A Guide for the Use of the Ferret Model for Influenza Virus Infection.The American journal of pathology · 2020Review
- Co-subsistence of avian influenza virus subtypes of low and high pathogenicity in Bangladesh: Challenges for diagnosis, risk assessment and control.Scientific reports · 2019Article
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry.PloS one · 2019Article
- Role of H7 hemagglutinin in murine infectivity of influenza viruses following ocular inoculation.Virology · 2017Article
- Review
- Oseltamivir inhibits influenza virus replication and transmission following ocular-only aerosol inoculation of ferrets.Virology · 2015Article
- A case-control study to identify risk factors associated with avian influenza subtype H9N2 on commercial poultry farms in Pakistan.PloS one · 2015Article
- Animal models for influenza viruses: implications for universal vaccine development.Pathogens (Basel, Switzerland) · 2014Review
- Prevalence and control of H7 avian influenza viruses in birds and humans.Epidemiology and infection · 2014Review
- Emergence of a highly pathogenic avian influenza virus from a low-pathogenic progenitor.Journal of virology · 2014Article
- Mammalian models for the study of H7 virus pathogenesis and transmission.Current topics in microbiology and immunology · 2014Review
- Genetic changes that accompanied shifts of low pathogenic avian influenza viruses toward higher pathogenicity in poultry.Virulence · 2013Review
- Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis.Journal of virology · 2013Article
- Ocular tropism of respiratory viruses.Microbiology and molecular biology reviews : MMBR · 2013Review
- Receptor characterization and susceptibility of cotton rats to avian and 2009 pandemic influenza virus strains.Journal of virology · 2013Article
- Innovations in modeling influenza virus infections in the laboratory.Trends in microbiology · 2012Review
- Influenza virus respiratory infection and transmission following ocular inoculation in ferrets.PLoS pathogens · 2012Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
H5 and H7 avian influenza viruses can become highly pathogenic in chickens after interspecies transmission. These viruses have transmitted directly to humans from birds in Eurasia and Africa (H5N1), the Netherlands (H7N7), and Canada (H7N3). Here we report antigenic, sequence, and phylogenetic analyses of H7N3 viruses isolated from chickens in Pakistan from 1995 to 2002. We compared the pathogenic and zoonotic potential of the Pakistani viruses in avian and mammalian hosts. In chickens, all of the isolates showed high pathogenicity with poor transmissibility to contact birds. Viral shedding from the trachea and cloaca was equivalent, but cloacal shedding occurred longer; dissemination of virus into the tissues was widespread. In contrast, the viruses replicated poorly in 6-week-old mallard ducks. In mammalian hosts, of the two Pakistani H7N3/02 viruses that caused weight loss, one also caused 40% mortality in mice without prior adaptation, and preliminary experiments in ferrets showed significant virus multiplication in the lungs, intestine, and conjunctiva. We conclude that the H7N3/02 isolates from Pakistan show limited antigenic drift and have evolved slowly during their 8-year circulation in chickens; however, these viruses have the potential to infect mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.