ArticleCritical care (London, England)2009
The impact of early hypoglycemia and blood glucose variability on outcome in critical illness.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02726958 (Early Postoperative Blood Glucose Variability and Outcome After TAVI), which is not on this map. Cited by 109 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Postoperative Blood Glucose Variability and Outcome After TAVI : a Retrospective Single-centre Study
Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it, 285 citations in OpenAlex.
- Glucose variability measures and their effect on mortality: a systematic review.Intensive care medicine · 2011Pooled it
- Diabetes-specific enteral nutrition formula in hyperglycemic, mechanically ventilated, critically ill patients: a prospective, open-label, blind-randomized, multicenter study.Critical care (London, England) · 2015Trial
- Pilot study of the SPRINT glycemic control protocol in a Hungarian medical intensive care unit.Journal of diabetes science and technology · 2012Trial
- Second pilot trials of the STAR-Liege protocol for tight glycemic control in critically ill patients.Biomedical engineering online · 2012Trial
- Implementing glucose control in intensive care: a multicenter trial using statistical process control.Intensive care medicine · 2010Trial
- Continuous Glucose Monitoring and Hypoglycaemia Risk During Paediatric DKA Treatment in the PICU: A Retrospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Microstructural white matter changes in infants with transient neonatal hypoglycemia revealed by diffusion tensor imaging: a preliminary cross-sectional study.Quantitative imaging in medicine and surgery · 2026Article
- Coefficient of variation-defined glycemic variability is associated with ICU mortality in critically ill influenza patients.BMC infectious diseases · 2026Article
- Association of glycemic variability with the risk of new-onset atrial fibrillation and death in critically ill patients without diabetes: analysis of the MIMIC-IV database.Diabetology & metabolic syndrome · 2026Article
- A Nomogram Prediction Model and Validation of Hypoglycemia Risk in Patients With Decompensated Cirrhosis and Type 2 Diabetes.Journal of diabetes research · 2026Article
- Accurate prediction of hypoglycemia and hyperglycemia using machine learning in critically ill patients.Scientific reports · 2025Article
- The additive effect of hemoglobin glycation index and glycemic variability to predict mortality in cardiac intensive care patients with and without diabetes.Scientific reports · 2025Article
- Joint impact of stress hyperglycaemic ratio and glycaemic variability in patients with ischaemic stroke and machine learning for mortality prediction.BMC neurology · 2025Article
- Association between glycemic variability in patients with traumatic lung injury and risk of in-hospital death: a retrospective analysis based on the Medical Information Mart for Intensive Care IV (MIMIC-IV) database.Journal of thoracic disease · 2025Article
- Rinaldo Bellomo's seminal contribution to observational research using the ANZICS CORE registry.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Review
- Non-Diabetic Hypoglycemia: Evaluation and Management in Adults.Journal of clinical medicine · 2025Review
- Glycemic variability and mortality in patients with aortic diseases: A multicenter retrospective cohort study.PloS one · 2025Article
- Association between glycemic variability and short-term mortality in patients with acute kidney injury: a retrospective cohort study of the MIMIC-IV database.Scientific reports · 2024Article
- Hyperglycemia and glucose variability are associated with worse survival in mechanically ventilated COVID-19 patients: the prospective Maastricht Intensive Care Covid Cohort.Diabetology & metabolic syndrome · 2023Article
- Association of glycemic variability with death and severe consciousness disturbance among critically ill patients with cerebrovascular disease: analysis of the MIMIC-IV database.Cardiovascular diabetology · 2023Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn critical illness, the association of hypoglycemia, blood glucose (BG) variability and outcome are not well understood. We describe the incidence, clinical factors and outcomes associated with an early hypoglycemia and BG variability in critically ill patients.
methodsRetrospective interrogation of prospectively collected data from the Australia New Zealand Intensive Care Society Adult Patient Database on 66184 adult admissions to 24 intensive care units (ICUs) from 1 January 2000 to 31 December 2005. Primary exposure was hypoglycemia (BG < 4.5 mmol/L) and BG variability (BG < 4.5 and >or= 12.0 mmol/L) within 24 hours of admission. Primary outcome was all-cause mortality.
resultsThe cumulative incidence of hypoglycemia and BG variability were 13.8% (95% confidence interval (CI) = 13.5 to 14.0; n = 9122) and 2.9% (95%CI = 2.8 to 3.0, n = 1913), respectively. Several clinical factors were associated with both hypoglycemia and BG variability including: co-morbid disease (P < 0.001), non-elective admissions (P < 0.001), higher illness severity (P < 0.001), and primary septic diagnosis (P < 0.001). Hypoglycemia was associated with greater odds of adjusted ICU (odds ratio (OR) = 1.41, 95% CI = 1.31 to 1.54) and hospital death (OR = 1.36, 95% CI = 1.27 to 1.46). Hypoglycemia severity was associated with 'dose-response' increases in mortality. BG variability was associated with greater odds of adjusted ICU (1.5, 95% CI = 1.4 to 1.6) and hospital (1.4, 95% CI = 1.3 to 1.5) mortality, when compared with either hypoglycemia only or neither.
conclusionsIn critically ill patients, both early hypoglycemia and early variability in BG are relatively common, and independently portend an increased risk for mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.