ReviewJournal of clinical hypertension (Greenwich, Conn.)2009
The risks and benefits of initial irbesartan/hydrochlorothiazide combination therapy in patients with severe hypertension.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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1 citing paper in PubMed, 3 citations in OpenAlex.
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2 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The impact of delays in blood pressure (BP) reduction is particularly relevant for patients with severe hypertension who are at risk for hypertensive emergencies. Combination therapies may hold promise as initial treatment for these patients. The safety and efficacy of initial irbesartan / hydrochlorothiazide (angiotensin receptor blocker / thiazide) treatment was compared with that of irbesartan as monotherapy in a multicenter, double-blind, parallel-group study in patients with severe hypertension. After 5 weeks, 47% of patients receiving combination therapy achieved a target diastolic BP <90 mm Hg compared with 33% with monotherapy (P=.0005). Similarly, systolic BP/ diastolic BP <140 / 90 mm Hg targets were reached by more subjects treated with combination therapy than subjects receiving monotherapy (34.6% vs 19.2%, P<.0001). Initial use of combination therapy instead of monotherapy is estimated to prevent between 250 and 4500 cardiovascular events in every 100,000 severely hypertensive patients over 5 years, without significantly increasing serious adverse event rates.
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