ArticleAmerican journal of medical genetics. Part A2009
Is there epidemiologic evidence to support vascular disruption as a pathogenesis of gastroschisis?
Article in American journal of medical genetics. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Medication use during pregnancy and the risk of gastroschisis: a systematic review and meta-analysis of observational studies.Orphanet journal of rare diseases · 2024Pooled it
- Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls.Human reproduction updatePooled it
- A rare combination of gastroschisis, jejunal atresia, colonic atresia, and midgut malrotation in a newborn: a case report and literature review.International journal of surgery case reports · 2026Article
- Descriptive epidemiology of gastroschisis in China from 2007 to 2020: a nationwide surveillance-based study.BMC pediatrics · 2024Article
- Prenatal cannabis use disorder and gastroschisis in California, 2007-19.International journal of epidemiology · 2024Article
- Public health priorities for gastroschisis: Summary of a meeting sponsored by the Centers for Disease Control and Prevention and the March of Dimes.Birth defects research · 2024Article
- Article
- The spectrum of brain malformations and disruptions in twins.American journal of medical genetics. Part A · 2021Article
- Regional variation in gastroschisis: a nationwide database review of demographics and outcomes.Pediatric surgery international · 2021Article
- Major birth defects in the Brazilian side of the triple border: a population-based cross-sectional study.Archives of public health = Archives belges de sante publique · 2020Article
- Delayed vasculogenesis and impaired angiogenesis due to altered Ang-2 and VE-cadherin levels in the chick embryo model following exposure to cadmium.Pediatric surgery international · 2016Article
- Challenges in Studying Modifiable Risk Factors for Birth Defects.Current epidemiology reports · 2015Article
- Maternal genitourinary infections and the risk of gastroschisis.American journal of epidemiology · 2014Article
- Maternal smoking, xenobiotic metabolizing enzyme gene variants, and gastroschisis risk.American journal of medical genetics. Part A · 2014Article
- Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects.International journal of hygiene and environmental health · 2014Article
- Maternal residential atrazine exposure and gastroschisis by maternal age.Maternal and child health journal · 2013Article
- A case-control study of maternal bathing habits and risk for birth defects in offspring.Environmental health : a global access science source · 2013Article
- Prevalence and correlates of gastroschisis in 15 states, 1995 to 2005.Obstetrics and gynecology · 2013Article
- The role of maternal stress in early pregnancy in the aetiology of gastroschisis: an incident case control study.PloS one · 2013Article
- Association between maternal age and birth defects of unknown etiology: United States, 1997-2007.Birth defects research. Part A, Clinical and molecular teratology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Gastroschisis is a congenital defect of the abdominal wall that occurs most commonly in the offspring of young women. The defect is often hypothesized to result from vascular disruption in the early embryo. We measured the associations between maternal vasoactive exposures in pregnancy, as possible markers of vascular disruption, and gastroschisis risk, using data collected as part of the National Birth Defects Prevention Study. Study participants included mothers of births from October 1997 to December 2003 in 10 states. The mothers of 514 gastroschisis cases were matched by age at delivery and state to 3,277 non-malformed controls and compared for periconceptional smoking and use of vasoconstrictors, non-steroidal anti-inflammatory drugs (NSAIDs), and vasodilators. Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CI) were estimated from conditional logistic regression. Case mothers were more likely than control mothers to smoke (OR = 1.5, 95% CI = 1.2-1.9) and report use of non-aspirin NSAIDs (1.4, 1.1-1.7) and anti-hypertensive vasodilators (2.6, 0.9-8.0), but not vasoconstrictive decongestants (1.0, 0.7-1.4). Cigarette smoking had little effect on gastroschisis risk in mothers <25 years of age, but the OR was 3.0 (1.8-5.0) for those >or=25 years. Likewise, ORs were greatest in the older women for use of non-aspirin NSAIDs (1.6, 1.0-2.6) and bronchodilators (3.0, 1.8-5.0). These findings suggest that, overall, vasoactive risk factors play a minor role in the etiology of gastroschisis, and do not support the vascular disruption hypothesis. However, the observation that increased ORs for some vasoactive exposures were confined to older women raises the question of whether inherent maternal factors might influence risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.