ReviewSeminars in immunopathology2009
Intestinal macrophages: differentiation and involvement in intestinal immunopathologies.
Review in Seminars in immunopathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 69 citations in OpenAlex.
- Phenotypic skewing of macrophages in vitro by secreted factors from colorectal cancer cells.PloS one · 2013Trial
- Macrophages in chronic infections: regulation and remodeling.Frontiers in immunology · 2025Review
- Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification.Nature genetics · 2024Article
- Article
- CRX-527 induced differentiation of HSCs protecting the intestinal epithelium from radiation damage.Frontiers in immunology · 2022Article
- Acacetin Ameliorates Experimental Colitis in Mice via Inhibiting Macrophage Inflammatory Response and Regulating the Composition of Gut Microbiota.Frontiers in physiology · 2020Article
- Functions of Macrophages in the Maintenance of Intestinal Homeostasis.Journal of immunology research · 2019Review
- PD-L1 is required for human endometrial regenerative cells-associated attenuation of experimental colitis in mice.American journal of translational research · 2019Article
- Peptidoglycan Suppresses Phagocytic Activities and Apoptosis of Macrophages in Colonic Mucosa Tissues of Crohn's Disease Patients and In Vitro.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- The Brain-Intestinal Mucosa-Appendix- Microbiome-Brain Loop.Diseases (Basel, Switzerland) · 2018Article
- Autofluorescence and Nonspecific Immunofluorescent Labeling in Frozen Bovine Intestinal Tissue Sections: Solutions for Multicolor Immunofluorescence Experiments.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.PLoS genetics · 2017Article
- Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions.Scientific reports · 2015Article
- Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk.Journal of innate immunity · 2015Article
- Regional specialization within the intestinal immune system.Nature reviews. Immunology · 2014Review
- Detection of enteric pathogens by the nodosome.Trends in immunology · 2014Review
- Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?World journal of gastroenterology · 2014Review
- Chemistry meets biology in colitis-associated carcinogenesis.Free radical research · 2013Review
- Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?Molecular neurobiology · 2013Review
- Macrophages: Good guys in colorectal cancer.Oncoimmunology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal macrophages, preferentially located in the subepithelial lamina propria, represent the largest pool of tissue macrophages in humans. As an adaptation to the local antigen- and bacteria-rich environment, intestinal macrophages exhibit several distinct phenotypic and functional characteristics. Notably, microbe-associated molecular pattern receptors, including the lipopolysaccharide (LPS) receptors CD14 and TLR4, and also the Fc receptors for IgA and IgG are absent on most intestinal macrophages under homeostatic conditions. Moreover, while macrophages in the intestinal mucosa are refractory to the induction of proinflammatory cytokine secretion, they still display potent phagocytic activity. These adaptations allow intestinal macrophages to comply with their main task, i.e., the efficient removal of microbes while maintaining local tissue homeostasis. In this paper, we review recent findings on the functional differentiation of monocyte subsets into distinct macrophage populations and on the phenotypic and functional adaptations that have evolved in intestinal macrophages in response to their antigen-rich environment. Furthermore, the involvement of intestinal macrophages in the pathogenesis of celiac disease and inflammatory bowel diseases is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.