ReviewSeminars in immunopathology2009
Mononuclear cells in liver fibrosis.
Review in Seminars in immunopathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 88 citations in OpenAlex.
- The roles of Th cells in myocardial infarction.Cell death discovery · 2024Review
- Potential anti-tumor effects of regulatory T cells in the tumor microenvironment: a review.Journal of translational medicine · 2024Review
- Menstrual blood-derived mesenchymal stem cells attenuate inflammation and improve the mortality of acute liver failure combining with A2AR agonist in mice.Journal of gastroenterology and hepatology · 2021Article
- A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair.Signal transduction and targeted therapy · 2021Review
- KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation.Archives of medical science : AMS · 2021Article
- Sphingosine 1-Phosphate Receptor Blockade Affects Pro-Inflammatory Bone Marrow-Derived Macrophages and Relieves Mouse Fatty Liver Injury.International journal of molecular sciences · 2019Article
- Immune suppression in chronic hepatitis B infection associated liver disease: A review.World journal of gastroenterology · 2019Review
- LOXL2-A New Target in Antifibrogenic Therapy?International journal of molecular sciences · 2019Review
- The innate immune receptor TREM-1 promotes liver injury and fibrosis.The Journal of clinical investigation · 2018Article
- T cell responses to tumor: how dominant assumptions on immune activity led to a neglect of pathological functions, and how evolutionary considerations can help identify testable hypotheses for improving immunotherapy.Cancer immunology, immunotherapy : CII · 2018Review
- Cytoplasmic domain of tissue factor promotes liver fibrosis in mice.World journal of gastroenterology · 2017Article
- Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- Reversal of liver cirrhosis: current evidence and expectations.The Korean journal of internal medicine · 2017Review
- The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis.Frontiers in physiology · 2017Review
- The Superficial Dermis May Initiate Keloid Formation: Histological Analysis of the Keloid Dermis at Different Depths.Frontiers in physiology · 2017Article
- Tailored chemokine receptor modification improves homing of adoptive therapy T cells in a spontaneous tumor model.Oncotarget · 2016Article
- A deleterious role for Th9/IL-9 in hepatic fibrogenesis.Scientific reports · 2016Article
- Restoring homeostasis of CD4⁺ T cells in hepatitis-B-virus-related liver fibrosis.World journal of gastroenterology · 2015Review
- Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice.Scientific reports · 2015Article
- Activated rat hepatic stellate cells influence Th1/Th2 profile in vitro.World journal of gastroenterology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms, including secretion of cytokines and generation of oxidative stress-related products. However, macrophages are also pivotal in the process of fibrosis resolution, where they contribute to matrix degradation. T lymphocytes modulate the fibrogenic process by direct interaction with myofibroblasts and secreting cytokines. In general, Th2 polarized responses promote fibrosis, while Th1 cytokines may be antifibrogenic. NK cells limit the development of fibrosis and favor its resolution, at least in part via killing of fibrogenic cells. The possible role of NKT cells and B cells is emerging in recent studies. Thus, mononuclear cells represent a critical regulatory system during fibrogenesis and may become an appealing target for therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.