Evidence map›Paper›PMID 19532096›Full record

ReviewCurrent opinion in allergy and clinical immunology2009

Rhinovirus and the initiation of asthma.

James E Gern

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in allergy and clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 95 citations in OpenAlex.

  1. Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2010
    Trial
  2. Article
  3. Article
  4. The respiratory tract virome: unravelling the role of viral dark matter in respiratory health and disease.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. The role of rhinovirus infections in young children with cystic fibrosis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020
    Article
  14. Lung functional development and asthma trajectories.Seminars in immunopathology · 2020
    Review
  15. Microbial diversity within the airway microbiome in chronic pediatric lung diseases.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

James E GernDivision of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin Medical School, Madison, Wisconsin 53792-9988, USA. gern@medicine.wisc.edu
University of Wisconsin–Madison · US

Funding

Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2002 to 2017
$31.3M
ZOSUQUIDAR TRIHYDROCHLORIDE IN NEWLY DIAGNOSED AMLM01RR003186 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MATLOUB, YOUSIF H · 1986 to 2007
$19.3M
RV-Mediated Mechanisms of Neutrophil Motility /InflammatU19AI070503 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BERTICS, PAUL JOHN · 2006 to 2010
$6.8M
T Regulatory Cells and Chilhood AsthmaR01HL080072 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2004 to 2008
$1.8M
Inner-City Asthma Consortium-266025496-266025496N01AI025496 · NIAID · UNIVERSITY OF WISCONSIN · PI BUSSE, WILLIAM · 2002 to 2006
–
NCRR NIH HHS M01 RR003186NHLBI NIH HHS P01 HL070831NHLBI NIH HHS R01 HL080072NIAID NIH HHS N01 AI025496NIAID NIH HHS U19 AI070503PHS HHS DAIT-02-11
6 · The paper itself

Abstract

purpose of reviewVirus-induced wheezing in infancy is a risk factor for asthma, and recent studies have highlighted the role of rhinoviruses in causing acute illnesses and as a possible contributing factor to chronic asthma. RECENT

findingsHuman rhinoviruses (HRVs) have long been known as the most common cause of common cold in infants and children. Recent developments in molecular diagnostics have led to the discovery of new viruses and have also provided data to implicate HRV as an important cause of lower respiratory infections and acute virus-induced wheezing in preschool children. In addition, HRV-induced wheezing episodes appear to identify children who are at increased risk for the subsequent development of childhood asthma. SUMMARY: Collectively, these findings raise the possibility that lower respiratory infections with pathogens such as HRV and respiratory syncytial virus could participate in the causation of asthma, especially in children with suboptimal antiviral defenses. A variety of experimental models and clinical studies have been used to identify possible mechanisms related to the infection and the ensuing host response that could disturb normal lung and immunologic development to promote asthma. Defining these relationships could lead to new therapeutic and preventive approaches to common forms of childhood asthma.

Indexed as

RhinovirusAsthmaChild, PreschoolHumansInfantInfant, NewbornPicornaviridae InfectionsRespiratory Tract Infections

Identifiers

PMID19532096
PMCPMC2760477
OpenAlexW1999604173

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.