ReviewCurrent opinion in neurology2009
Cognitive abilities and behaviour of children exposed to antiepileptic drugs in utero.
Review in Current opinion in neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child.The Cochrane database of systematic reviews · 2014Pooled it
- Anti-seizure Medication Induced Cognitive Impairment in Children with Epilepsy: A Narrative Review.Iranian journal of child neurology · 2025Review
- Expert opinion: use of valproate in girls and women of childbearing potential with epilepsy: recommendations and alternatives based on a review of the literature and clinical experience-a European perspective.Journal of neurology · 2021Review
- Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism.BMC complementary and alternative medicine · 2017Article
- Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder.Pharmacological reviews · 2013Review
- Article
- Neurological perspectives on voltage-gated sodium channels.Brain : a journal of neurology · 2012Review
- Neonatal exposure to antiepileptic drugs disrupts striatal synaptic development.Annals of neurology · 2012Article
- Antiepileptic drugs and pregnancy outcomes.American journal of medical genetics. Part A · 2012Review
- Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette.The European journal of neuroscience · 2012Review
- Psychoactive pharmaceuticals induce fish gene expression profiles associated with human idiopathic autism.PloS one · 2012Article
- Validating γ oscillations and delayed auditory responses as translational biomarkers of autism.Biological psychiatry · 2010Article
- The Use of Antiepileptic Drugs (AEDs) for the Treatment of Pediatric Aggression and Mood Disorders.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Teratogenic effects of antiepileptic drugs.Expert review of neurotherapeutics · 2010Review
- The 2008 Judith Hoyer lecture: epilepsy in children: listening to mothers.Epilepsy & behavior : E&B · 2009Review
- The Neurotoxic Mechanisms of Valproic Acid and Their Association With Neurodevelopmental Disorders: A Narrative Review.Basic and clinical neuroscienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewThe last two decades have witnessed a growing concern over the treatment of epilepsy in women of childbearing age, with an increased risk of major congenital malformations and possible cognitive difficulties associated with certain antiepileptic drugs. The aim here is to review the literature regarding the possible cognitive and behavioural impact of exposure to antiepileptic drugs in utero. RECENT
findingsRecent evidence from large prospective cohorts indicates that there is a longer term risk to the cognitive and behavioural development of the child exposed in utero to sodium valproate. Information on other antiepileptic agents is conflicting or nonexistent and more research in this area is urgently required. SUMMARY: Despite the methodological shortfalls of some of the research in this area, there is an accumulation of evidence highlighting an increased risk for cognitive and behavioural difficulties in children exposed to sodium valproate in utero. Although less certain, there may also be risks associated with phenobarbital and phenytoin exposure. Information regarding these risks should be communicated to the potential mother who has epilepsy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.