ArticleThe Plant cell2009
Mutation of the membrane-associated M1 protease APM1 results in distinct embryonic and seedling developmental defects in Arabidopsis.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- The haplotype-resolved and near-telomere-to-telomere genome assembly for the autotetraploid alfalfa.Plant communications · 2026Article
- Review
- The evolution of strictly monofunctional naphthoquinol C-methyltransferases is vital in cyanobacteria and plastids.The Plant cell · 2023Article
- Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme.The New phytologist · 2022Article
- Construction of prediction models for growth traits of soybean cultivars based on phenotyping in diverse genotype and environment combinations.DNA research : an international journal for rapid publication of reports on genes and genomes · 2022Article
- Protein-protein interactions in plant antioxidant defense.Frontiers in plant science · 2022Review
- Naphthylphthalamic acid associates with and inhibits PIN auxin transporters.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Efficient and accurate identification of protein complexes from protein-protein interaction networks based on the clustering coefficient.Computational and structural biotechnology journal · 2021Article
- A Retro-Perspective on Auxin Transport.Frontiers in plant science · 2021Article
- Auxin regulates adventitious root formation in tomato cuttings.BMC plant biology · 2019Article
- Stress-Induced Microspore Embryogenesis Requires Endogenous Auxin Synthesis and Polar Transport in Barley.Frontiers in plant science · 2019Article
- Bacillus methylotrophicus M4-96 isolated from maize (Zea mays) rhizoplane increases growth and auxin content in Arabidopsis thaliana via emission of volatiles.Protoplasma · 2017Article
- Cell wall targeted in planta iron accumulation enhances biomass conversion and seed iron concentration in Arabidopsis and rice.Plant biotechnology journal · 2016Article
- TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics.The Plant cell · 2016Article
- Candidate gene selection and detailed morphological evaluations of fs8.1, a quantitative trait locus controlling tomato fruit shape.Journal of experimental botany · 2015Article
- Maize LAZY1 mediates shoot gravitropism and inflorescence development through regulating auxin transport, auxin signaling, and light response.Plant physiology · 2013Article
- Cytoplasm localization of aminopeptidase M1 and its functional activity in root hair cells and BY-2 cells.Molecular biology reports · 2012Article
- ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis.Nature communications · 2012Article
- Plant leucine aminopeptidases moonlight as molecular chaperones to alleviate stress-induced damage.The Journal of biological chemistry · 2012Article
- Quantitative analysis of lateral root development: pitfalls and how to avoid them.The Plant cell · 2012Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
Aminopeptidase M1 (APM1), a single copy gene in Arabidopsis thaliana, encodes a metallopeptidase originally identified via its affinity for, and hydrolysis of, the auxin transport inhibitor 1-naphthylphthalamic acid (NPA). Mutations in this gene result in haploinsufficiency. Loss-of-function mutants show irregular, uncoordinated cell divisions throughout embryogenesis, affecting the shape and number of cotyledons and the hypophysis, and is seedling lethal at 5 d after germination due to root growth arrest. Quiescent center and cell cycle markers show no signals in apm1-1 knockdown mutants, and the ground tissue specifiers SHORTROOT and SCARECROW are misexpressed or mislocalized. apm1 mutants have multiple, fused cotyledons and hypocotyls with enlarged epidermal cells with cell adhesion defects. apm1 alleles show defects in gravitropism and auxin transport. Gravistimulation decreases APM1 expression in auxin-accumulating root epidermal cells, and auxin treatment increases expression in the stele. On sucrose gradients, APM1 occurs in unique light membrane fractions. APM1 localizes at the margins of Golgi cisternae, plasma membrane, select multivesicular bodies, tonoplast, dense intravacuolar bodies, and maturing metaxylem cells. APM1 associates with brefeldin A-sensitive endomembrane structures and the plasma membrane in cortical and epidermal cells. The auxin-related phenotypes and mislocalization of auxin efflux proteins in apm1 are consistent with biochemical interactions between APM1 and NPA.
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