ArticleDevelopmental cell2009
Dynamin participates in the maintenance of anterior polarity in the Caenorhabditis elegans embryo.
Article in Developmental cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Asymmetric distribution of actin-related proteins in the earlybioRxiv : the preprint server for biology · 2026Article
- A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis.Journal of cell science · 2025Article
- Formation of Drosophila germ cells requires spatial patterning of phospholipids.Current biology : CB · 2025Article
- A role for BYN-1/bystin in cellular uptake and clearance of residual bodies in the Caenorhabditis elegans germline.Development (Cambridge, England) · 2024Article
- Mechanisms of action of NME metastasis suppressors - a family affair.Cancer metastasis reviews · 2023Review
- The biosynthetic-secretory pathway, supplemented by recycling routes, determines epithelial membrane polarity.Science advances · 2023Article
- Visualizing Phagocytic Cargo In Vivo from Engulfment to Resolution in Caenorhabditis elegans.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Anterior-enriched filopodia create the appearance of asymmetric membrane microdomains in polarizingJournal of cell science · 2019Article
- The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity.Development (Cambridge, England) · 2017Review
- Regulation of Cell Polarity by PAR-1/MARK Kinase.Current topics in developmental biology · 2017Review
- Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair.The Journal of cell biology · 2015Article
- Dynamin regulates metaphase furrow formation and plasma membrane compartmentalization in the syncytial Drosophila embryo.Biology open · 2015Article
- Endocytosis, signaling, and beyond.Cold Spring Harbor perspectives in biology · 2014Review
- Smed-dynA-1 is a planarian nervous system specific dynamin 1 homolog required for normal locomotion.Biology open · 2014Article
- Single-molecule analysis of cell surface dynamics in Caenorhabditis elegans embryos.Nature methods · 2014Article
- C. elegans as a model for membrane traffic.WormBook : the online review of C. elegans biology · 2014Review
- F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo.Molecular biology of the cell · 2013Article
- WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia.Developmental biology · 2013Article
- Principles of PAR polarity in Caenorhabditis elegans embryos.Nature reviews. Molecular cell biology · 2013Review
- PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.Development (Cambridge, England) · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Cell polarity is crucial for the generation of cell diversity. Recent evidence suggests that the actin cytoskeleton plays a key role in establishment of embryonic polarity, yet the mechanisms that maintain polarity cues in particular membrane domains during development remain unclear. Dynamin, a large GTPase, functions in both endocytosis and actin dynamics. Here, the Caenorhabditis elegans dynamin ortholog, DYN-1, maintains anterior polarity cues. DYN-1-GFP foci are enriched in the anterior cortex in a manner dependent on the anterior polarity proteins, PAR-6 and PKC-3. Membrane internalization and actin comet formation are enriched in the anterior, and are dependent on DYN-1. PAR-6-labeled puncta are also internalized from cortical accumulations of DYN-1-GFP. Our results demonstrate a mechanism for the spatial and temporal regulation of endocytosis in the anterior of the embryo, contributing to the precise localization and maintenance of polarity factors within a dynamic plasma membrane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.