ArticleAnnals of clinical microbiology and antimicrobials2009
Genetic relatedness and molecular characterization of multidrug resistant Acinetobacter baumannii isolated in central Ohio, USA.
Article in Annals of clinical microbiology and antimicrobials, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference toPathogens (Basel, Switzerland) · 2024Review
- Different Efflux Pump Systems in Acinetobacter baumannii and Their Role in Multidrug Resistance.Advances in experimental medicine and biology · 2023Review
- Deciphering the virulence factors, regulation, and immune response toFrontiers in cellular and infection microbiology · 2023Review
- Dynamic Gene Clusters Mediating Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Antibiotic Susceptibility, Clonality, and Molecular Characterization of Carbapenem-Resistant Clinical Isolates ofInternational journal of microbiology · 2020Article
- Tetracycline resistance mediated by tet efflux pumps in clinical isolates of Acinetobacter baumannii.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Distribution of Class D Carbapenemase and Extended-Spectrum β-Lactamase Genes amongJournal of clinical and diagnostic research : JCDR · 2017Article
- Molecular Characterization of Multidrug Resistant Strains ofJournal of clinical and diagnostic research : JCDR · 2017Article
- Molecular characterization and antimicrobial susceptibility of Acinetobacter baumannii isolates obtained from two hospital outbreaks in Los Angeles County, California, USA.BMC infectious diseases · 2016Article
- Occurrence of Diverse Antimicrobial Resistance Determinants in Genetically Unrelated Biocide Tolerant Klebsiella pneumoniae.PloS one · 2016Article
- Investigation of the molecular epidemiology of Acinetobacter baumannii isolated from patients and environmental contamination.The Journal of antibiotics · 2015Article
- Molecular characterization of extended-spectrum beta-lactamases (ESBLs) produced by clinical isolates of Acinetobacter baumannii in Saudi Arabia.Annals of clinical microbiology and antimicrobials · 2015Article
- AbuO, a TolC-like outer membrane protein of Acinetobacter baumannii, is involved in antimicrobial and oxidative stress resistance.Antimicrobial agents and chemotherapy · 2015Article
- Drug-resistant gene of blaOXA-23, blaOXA-24, blaOXA-51 and blaOXA-58 in Acinetobacter baumannii.International journal of clinical and experimental medicine · 2015Article
- Detection of AdeABC efflux pump genes in tetracycline-resistant Acinetobacter baumannii isolates from burn and ventilator-associated pneumonia patients.Journal of pharmacy & bioallied sciences · 2014Article
- Epidemiological characterizations of class 1 integrons from multidrug-resistant acinetobacter isolates in Daejeon, Korea.Annals of laboratory medicine · 2014Article
- Evaluation of Ciprofloxacin (gyrA, parC Genes) and Tetracycline (tetB Gene) Resistance in Nosocomial Acinetobacter baumannii Infections.Jundishapur journal of microbiology · 2014Article
- Phenotypic and genotypic characteristics of tetracycline resistant Acinetobacter baumannii isolates from nosocomial infections at Tehran hospitals.Iranian journal of basic medical sciences · 2014Article
- Emergence and spread of plasmid-borne tet(B)::ISCR2 in minocycline-resistant Acinetobacter baumannii isolates.Antimicrobial agents and chemotherapy · 2013Article
- Expression of ESBL-like activity in infrequently encountered members of the family Enterobacteriaceae.Current microbiology · 2012Article
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8 authors.
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Abstract
backgroundOver the last decade, nosocomial infections due to Acinetobacter baumannii have been described with an increasing trend towards multidrug resistance, mostly in intensive care units. The aim of the present study was to determine the clonal relatedness of clinical isolates and to elucidate the genetic basis of imipenem resistance.
methodsA. baumannii isolates (n = 83) originated from two hospital settings in central Ohio were used in this study. Pulsed-field gel electrophoresis genotyping and antimicrobial susceptibility testing for clinically relevant antimicrobials were performed. Resistance determinants were characterized by using different phenotypic (accumulation assay for efflux) and genotypic (PCR, DNA sequencing, plasmid analysis and electroporation) approaches.
resultsThe isolates were predominantly multidrug resistant (>79.5%) and comprised of thirteen unique pulsotypes, with genotype VII circulating in both hospitals. The presence of bla(OXA-23) in 13% (11/83) and IS(Aba1) linked bla(OXA-66) in 79.5% (66/83) of clinical isolates was associated with high level imipenem resistance. In this set of OXA producing isolates, multidrug resistance was bestowed by bla(ADC-25), class 1 integron-borne aminoglycoside modifying enzymes, presence of sense mutations in gyrA/parC and involvement of active efflux (with evidence for the presence of adeB efflux gene).
conclusionThis study underscores the major role of carbapenem-hydrolyzing class D beta-lactamases, and in particular the acquired OXA-23, in the dissemination of imipenem-resistant A. baumannii. The co-occurrence of additional resistance determinant could also be a significant threat.
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