ArticleBMC biology2009
Early calcium increase triggers the formation of olfactory long-term memory in honeybees.
Article in BMC biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Never underestimate honeybees: Their exceptionally diverse adaptive strategies.Journal of advanced research · 2026Review
- Parallel mechanisms of visual memory formation across distinct regions of the honey bee brain.The Journal of experimental biology · 2021Article
- Regulation ofFrontiers in neuroscience · 2021Article
- Plasticity and modulation of olfactory circuits in insects.Cell and tissue research · 2021Review
- Honey bees long-lasting locomotor deficits after exposure to the diamide chlorantraniliprole are accompanied by brain and muscular calcium channels alterations.Scientific reports · 2019Article
- Cyclic AMP-dependent plasticity underlies rapid changes in odor coding associated with reward learning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Pharmacologic inhibition of phospholipase C in the brain attenuates early memory formation in the honeybee (Biology open · 2018Article
- Kenyon Cell Subtypes/Populations in the Honeybee Mushroom Bodies: Possible Function Based on Their Gene Expression Profiles, Differentiation, Possible Evolution, and Application of Genome Editing.Frontiers in psychology · 2018Review
- Honeybee locomotion is impaired by Am-CaScientific reports · 2017Article
- Candidate genes for individual recognition in Polistes fuscatus paper wasps.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- DNA Methylation Adjusts the Specificity of Memories Depending on the Learning Context and Promotes Relearning in Honeybees.Frontiers in molecular neuroscience · 2016Article
- Activation of NO-cGMP Signaling Rescues Age-Related Memory Impairment in Crickets.Frontiers in behavioral neuroscience · 2016Article
- Field populations of native Indian honey bees from pesticide intensive agricultural landscape show signs of impaired olfaction.Scientific reports · 2015Article
- Molecular mechanisms underlying formation of long-term reward memories and extinction memories in the honeybee (Apis mellifera).Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- Novel biopesticide based on a spider venom peptide shows no adverse effects on honeybees.Proceedings. Biological sciences · 2014Article
- Experience teaches plants to learn faster and forget slower in environments where it matters.Oecologia · 2014Article
- The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms.Cellular and molecular life sciences : CMLS · 2014Review
- Characterization of the first honeybee Ca²⁺ channel subunit reveals two novel species- and splicing-specific modes of regulation of channel inactivation.Pflugers Archiv : European journal of physiology · 2013Article
- Friends and foes from an ant brain's point of view--neuronal correlates of colony odors in a social insect.PloS one · 2011Article
- Calcium and neurogenesis in Alzheimer's disease.Frontiers in neuroscience · 2010Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSynaptic plasticity associated with an important wave of gene transcription and protein synthesis underlies long-term memory processes. Calcium (Ca2+) plays an important role in a variety of neuronal functions and indirect evidence suggests that it may be involved in synaptic plasticity and in the regulation of gene expression correlated to long-term memory formation. The aim of this study was to determine whether Ca2+ is necessary and sufficient for inducing long-term memory formation. A suitable model to address this question is the Pavlovian appetitive conditioning of the proboscis extension reflex in the honeybee Apis mellifera, in which animals learn to associate an odor with a sucrose reward.
resultsBy modulating the intracellular Ca2+ concentration ([Ca2+]i) in the brain, we show that: (i) blocking [Ca2+]i increase during multiple-trial conditioning selectively impairs long-term memory performance; (ii) conversely, increasing [Ca2+]i during single-trial conditioning triggers long-term memory formation; and finally, (iii) as was the case for long-term memory produced by multiple-trial conditioning, enhancement of long-term memory performance induced by a [Ca2+]i increase depends on de novo protein synthesis.
conclusionAltogether our data suggest that during olfactory conditioning Ca2+ is both a necessary and a sufficient signal for the formation of protein-dependent long-term memory. Ca2+ therefore appears to act as a switch between short- and long-term storage of learned information.
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