ArticleJournal of fish diseases2009
Husbandry stress exacerbates mycobacterial infections in adult zebrafish, Danio rerio (Hamilton).
Article in Journal of fish diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 88 citations in OpenAlex.
- Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b.Veterinary microbiology · 2015Trial
- Chains of Commerce: A Comprehensive Review of Animal Welfare Impacts in the International Wildlife Trade.Animals : an open access journal from MDPI · 2025Review
- Acute clomipramine exposure elicits dose-dependent surfacing behavior in adult zebrafish (PeerJ · 2024Article
- Disentangling the link between zebrafish diet, gut microbiome succession, and Mycobacterium chelonae infection.Animal microbiome · 2023Article
- Ruff Morning? The Use of Environmental Enrichment during an Acute Stressor in Kenneled Shelter Dogs.Animals : an open access journal from MDPI · 2023Article
- Common laboratory diets differentially influence zebrafish gut microbiome's successional development and sensitivity to pathogen exposure.Research square · 2023Article
- Improving zebrafish laboratory welfare and scientific research through understanding their natural history.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Article
- Identification of Individual Zebrafish (Animals : an open access journal from MDPI · 2021Article
- Screening selected medicinal plants for potential anxiolytic activity using an in vivo zebrafish model.Psychopharmacology · 2020Article
- Source or Sink: Examining the Role of Biofilms in Transmission of Mycobacterium spp. in Laboratory Zebrafish.Zebrafish · 2019Article
- Article
- Mycobacterium marinum.Microbiology spectrum · 2017Review
- Recommendations for Health Monitoring and Reporting for Zebrafish Research Facilities.Zebrafish · 2016Article
- Effects of Subclinical Mycobacterium chelonae Infections on Fecundity and Embryo Survival in Zebrafish.Zebrafish · 2016Article
- Article
- Controlling Endemic Pathogens-Challenges and Opportunities.Zebrafish · 2016Article
- Article
- Aquatic environment, housing, and management in the eighth edition of the Guide for the Care and Use of Laboratory Animals: additional considerations and recommendations.Journal of the American Association for Laboratory Animal Science : JAALAS · 2012Article
- The challenges of implementing pathogen control strategies for fishes used in biomedical research.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mycobacteria are significant pathogens of laboratory zebrafish, Danio rerio (Hamilton). Stress is often implicated in clinical disease and morbidity associated with mycobacterial infections but has yet to be examined with zebrafish. The aim of this study was to examine the effects of husbandry stressors on zebrafish infected with mycobacteria. Adult zebrafish were exposed to Mycobacterium marinum or Mycobacterium chelonae, two species that have been associated with disease in zebrafish. Infected fish and controls were then subjected to chronic crowding and handling stressors and examined over an 8-week period. Whole-body cortisol was significantly elevated in stressed fish compared to non-stressed fish. Fish infected with M. marinum ATCC 927 and subjected to husbandry stressors had 14% cumulative mortality while no mortality occurred among infected fish not subjected to husbandry stressors. Stressed fish, infected with M. chelonae H1E2 from zebrafish, were 15-fold more likely to be infected than non-stressed fish at week 8 post-injection. Sub-acute, diffuse infections were more common among stressed fish infected with M. marinum or M. chelonae than non-stressed fish. This is the first study to demonstrate an effect of stress and elevated cortisol on the morbidity, prevalence, clinical disease and histological presentation associated with mycobacterial infections in zebrafish. Minimizing husbandry stress may be effective at reducing the severity of outbreaks of clinical mycobacteriosis in zebrafish facilities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.