ArticleGenes, chromosomes & cancer2009
Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice.
Article in Genes, chromosomes & cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Tcf-1 promotes genomic instability and T cell transformation in response to aberrant β-catenin activation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis.Genes & development · 2021Article
- Hypomorphic mTOR Downregulates CDK6 and Delays Thymic Pre-T LBL Tumorigenesis.Molecular cancer therapeutics · 2020Article
- Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis.Scientific reports · 2020Article
- Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas.Journal of cellular physiology · 2018Article
- The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling.Oncotarget · 2017Article
- Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma.Cancer research · 2016Article
- Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice.Cancer biology & therapy · 2015Article
- β-Catenin induces T-cell transformation by promoting genomic instability.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Murine mantle cell lymphoma model cell line.Leukemia · 2013Article
- Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.Blood · 2012Article
- Transcription Factor DLX5 As a New Target for Promising Antitumor Agents.Acta naturae · 2011Article
- GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The oncogene v-akt was isolated from a retrovirus that induced naturally occurring thymic lymphomas in AKR mice. We hypothesized that constitutive activation of Akt2 could serve as a first hit for the clonal expansion of malignant T-cells by promoting cell survival and genomic instability, leading to chromosome alterations. Furthermore, genes that cooperate with Akt2 to promote malignant transformation may reside at translocation/inversion junctions found in spontaneous thymic lymphomas from transgenic mice expressing constitutively active Akt2 specifically in T cells. Cytogenetic analysis revealed that thymic tumors from multiple founder lines exhibited either of two recurrent chromosomal rearrangements, inv(6)(A2B1) or t(14;15)(C2;D1). Fluorescence in situ hybridization, array CGH, and PCR analysis were used to delineate the inv(6) and t(14;15) breakpoints. Both rearrangements involved T-cell receptor loci. The inv(6) results in robust upregulation of the homeobox/transcription factor gene Dlx5 because of its relocation near the Tcrb enhancer. The t(14;15) places the Tcra enhancer in the vicinity of the Myc proto-oncogene, resulting in upregulated Myc expression. These findings suggest that activation of the Akt pathway can act as the initial hit to promote cell survival and genomic instability, whereas the acquisition of T-cell-specific overexpression of Dlx5 or Myc leads to lymphomagenesis.
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