ReviewIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Minimal hepatic encephalopathy.
Review in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Probiotics for people with hepatic encephalopathy.The Cochrane database of systematic reviews · 2017Pooled it
- Minimal Hepatic Encephalopathy: A Narrative Review.Cureus · 2026Review
- Psychometric Hepatic Encephalopathy Tests and Electroencephalogram Results Among Cirrhotic Patients.Medicina (Kaunas, Lithuania) · 2024Article
- Functional connectivity disruption of insular subregions in the cirrhotic patients with minimal hepatic encephalopathy.Brain imaging and behavior · 2024Article
- EncephalApp Stroop Test for covert hepatic encephalopathy screening in Tunisian cirrhotic patients.F1000Research · 2022Article
- A Comprehensive Review Evaluating the Impact of Protein Source (Vegetarian vs. Meat Based) in Hepatic Encephalopathy.Nutrients · 2021Review
- Oridonin prevents insulin resistance-mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy.Journal of cellular and molecular medicine · 2020Article
- Prevalence of minimal hepatic encephalopathy among patients with chronic liver disease in Ilorin, Nigeria.Ghana medical journal · 2019Article
- An E-Nose for the Monitoring of Severe Liver Impairment: A Preliminary Study.Sensors (Basel, Switzerland) · 2019Article
- Application of tabu search-based Bayesian networks in exploring related factors of liver cirrhosis complicated with hepatic encephalopathy and disease identification.Scientific reports · 2019Article
- Mitochondrial dysfunctions contribute to energy deficits in rodent model of hepatic encephalopathy.Metabolic brain disease · 2018Article
- Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy.Aging and disease · 2017Article
- Frontal assessment battery: A tool for screening minimal hepatic encephalopathy?World journal of hepatology · 2016Article
- Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy.Gastroenterology research and practice · 2016Article
- Minimal hepatic encephalopathy impairs quality of life.Journal of clinical and experimental hepatology · 2015Review
- Pannexin1 as a novel cerebral target in pathogenesis of hepatic encephalopathy.Metabolic brain disease · 2014Article
- Assessing inter- and intra-individual cognitive variability in patients at risk for cognitive impairment: the case of minimal hepatic encephalopathy.Metabolic brain disease · 2014Article
- Abnormal baseline brain activity in patients with HBV-related cirrhosis without overt hepatic encephalopathy revealed by resting-state functional MRI.Metabolic brain disease · 2013Article
- Dopamine from cirrhotic liver contributes to the impaired learning and memory ability of hippocampus in minimal hepatic encephalopathy.Hepatology international · 2013Article
- Correlation between degree and quality of sleep disturbance and the level of neuropsychiatric impairment in patients with liver cirrhosis.Metabolic brain disease · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minimal hepatic encephalopathy (MHE) is the mildest form of spectrum of hepatic encephalopathy (HE). Patients with MHE have no recognizable clinical symptoms of HE but have mild cognitive and psychomotor deficits. The prevalence of MHE is high in patients with cirrhosis of liver and varies between 30% and 84%; it is higher in patients with poor liver function. The diagnostic criteria for MHE have not been standardized but rest on careful patient history and physical examination, normal mental status examination, demonstration of abnormalities in cognition and/or neurophysiological function, and exclusion of concomitant neurological disorders. MHE is associated with impaired health-related quality of life, predicts the development of overt HE and is associated with poor survival. Hence, screening all patients with cirrhosis for MHE using psychometric tests, and treatment of those patients diagnosed to have MHE has been recommended. Ammonia plays a key role in the pathogenesis of MHE, which is thought to be similar to that of overt HE. Thus, ammonia-lowering agents such as lactulose and probiotics have been tried. These agents have been shown to improve cognitive and psychometric deficits, and have good safety profile. Future studies will better define the role of other drugs, such as rifaximin, acetyl L-carnitine and L-ornithine L-aspartate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.