ArticleClinical rheumatology2009
Peripheral bone density in patients with rheumatoid arthritis.
Article in Clinical rheumatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Concurrent effects of high-intensity interval training and vitamin D supplementation on bone metabolism among women diagnosed with osteoporosis: a randomized controlled trial.BMC musculoskeletal disorders · 2025Trial
- Revision total elbow replacement.Journal of clinical orthopaedics and trauma · 2021Review
- Article
- Benefits of exercise in rheumatoid arthritis.Journal of aging research · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone loss in patients with rheumatoid arthritis (RA) varies at different skeletal sites. The aim of the study was to evaluate whether bone mineral density (BMD) of the forearm is significantly different in patients with RA and controls and may correlate to BMD or other parameters of inflammation or bone resorption. We included 421 patients (357 women: mean age 58.4 +/- 12.87 years and 64 men: mean age 56.11 +/- 12.80 years) with RA in the study. BMD values of the ultradistal forearm (0.381 +/- 0.052 g/cm(2)) and middistal forearm (0.519 +/- 0.091 g/cm(2)) were significantly (p < 0.01) lower in women with RA than controls (0.395 +/- 0.043 and 0.535 +/- 0.052 g/cm(2), respectively). In contrast, there was no difference in bone density at the lumbar spine (women 0.921 +/- 0.1570 g/cm(2), men 0.941 +/- 0.144 g/cm(2)) or hip (women 08.11 +/- 0.140 g/cm(2), men 0.895 +/- 0.143 g/cm(2)) in patients with RA in comparison to controls (lumbar spine: women 0.930 +/- 0.146 g/cm(2); men 0.960 +/- 0.146 g/cm(2); hip: women 0.820 +/- 0.122 g/cm(2); men 0.899 +/- 0.144/cm(2)). Patients with increased inflammatory activity (elevated C-reactive protein) presented with significantly lower BMD of the hip (0.7533 +/- 0.144 versus 0.825 +/- 0.138 g/cm(2)) and ultradistal forearm (0.366 +/- 0.09 versus 0.390 +/- 0.07 g/cm(2)). This was not the case for the lumbar spine. BMD of the forearm is precise and, in contrast to BMD of the lumbar spine, significantly lower in patients with RA. It is related to inflammatory activity, grip strength, and treatment with glucocorticoids in patients with RA.
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Registered trials
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