ArticleMolecular plant2009
A major role of the MEKK1-MKK1/2-MPK4 pathway in ROS signalling.
Article in Molecular plant, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
118 citing papers in PubMed, 287 citations in OpenAlex.
- From Rhizosphere to Endosphere: Conserved and Specialised Mechanisms of Plant Growth-Promoting Bacteria in Mediating Salt Tolerance.Plant, cell & environment · 2026Review
- Evolutionary analysis ofFrontiers in plant science · 2026Article
- GmMEKK2 Disrupts the MKK1/2-MPK4 Cascade to Amplify Immune Signalling and Confer Enhanced Resistance to Soybean Mosaic Virus.Molecular plant pathology · 2025Article
- Article
- Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses.Frontiers in plant science · 2025Review
- Overexpression of MEKK18 from Arabidopsis pumila in rice significantly enhances stress resistance at the early stage.PloS one · 2025Article
- The Role of Female and Male Genes in Regulating Pollen Tube Guidance in Flowering Plants.Genes · 2024Review
- Understanding of Plant Salt Tolerance Mechanisms and Application to Molecular Breeding.International journal of molecular sciences · 2024Review
- An Overview of the Mechanisms through Which Plants Regulate ROS Homeostasis under Cadmium Stress.Antioxidants (Basel, Switzerland) · 2024Review
- Development of super-infective ternary vector systems for enhancing theHorticulture research · 2024Article
- Soybean MKK2 establishes intricate signalling pathways to regulate soybean response to cyst nematode infection.Molecular plant pathology · 2024Article
- Genome-wide identification ofFrontiers in genetics · 2024Article
- Comparative Transcriptomics and Metabolomics Analyses ofInternational journal of molecular sciences · 2023Article
- The GhMAP3K62-GhMKK16-GhMPK32 kinase cascade regulates drought tolerance by activating GhEDT1-mediated ABA accumulation in cotton.Journal of advanced research · 2023Article
- Comparative Transcriptome Analysis of Defense Response of Potato toPlants (Basel, Switzerland) · 2023Article
- How Plants Tolerate Salt Stress.Current issues in molecular biology · 2023Review
- Specificity models in MAPK cascade signaling.FEBS open bio · 2023Review
- VqMAPK3/VqMAPK6, VqWRKY33, andHorticulture research · 2023Article
- SoybeanInternational journal of molecular sciences · 2023Article
- Potato protein tyrosine phosphatase StPTP1a is activated by StMKK1 to negatively regulate plant immunity.Plant biotechnology journal · 2023Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last few years, it has become evident that reactive oxygen species (ROS) signalling plays an important role in various physiological responses, including pathogen defense and stomatal opening/closure. On the other hand, ROS overproduction is detrimental for proper plant growth and development, indicating that the regulation of an appropriate redox balance is essential for plants. ROS homeostasis in plants involves the mitogen-activated protein kinase (MAPK) pathway consisting of the MAPK kinase kinase MEKK1 and the MAPK MPK4. Phenotypic and molecular analysis revealed that the MAPK kinases MKK1 and MKK2 are part of a cascade, regulating ROS and salicylic acid (SA) accumulation. Gene expression analysis shows that of 32 transcription factors reported to be highly responsive to multiple ROS-inducing conditions, 20 are regulated by the MEKK1, predominantly via the MEKK1-MKK1/2-MPK4 pathway. However, MEKK1 also functions on other as yet unknown pathways and part of the MEKK1-dependent MPK4 responses are regulated independently of MKK1 and MKK2. Overall, this analysis emphasizes the central role of this MAPK cascade in oxidative stress signalling, but also indicates the high level of complexity revealed by this signalling network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.