ArticlePloS one2009
SNX4 in complex with clathrin and dynein: implications for endosome movement.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Assembly and fission of tubular carriers mediating protein sorting in endosomes.Nature reviews. Molecular cell biology · 2024Review
- CHC22 clathrin recruitment to the early secretory pathway requires two-site interaction with SNX5 and p115.The EMBO journal · 2024Article
- Choreographing the motor-driven endosomal dance.Journal of cell science · 2023Review
- A brain proteomic signature of incipient Alzheimer's disease in youngScience advances · 2021Article
- A heterodimeric SNX4--SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly.Journal of cell science · 2020Article
- Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein.Neuro-degenerative diseases · 2018Article
- A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin.Molecular biology of the cell · 2017Article
- Updated Insight into the Physiological and Pathological Roles of the Retromer Complex.International journal of molecular sciences · 2017Review
- Biogenesis of endosome-derived transport carriers.Cellular and molecular life sciences : CMLS · 2015Review
- α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.PloS one · 2014Article
- SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.Journal of cell science · 2013Article
- Microtubule motors mediate endosomal sorting by maintaining functional domain organization.Journal of cell science · 2013Article
- Clathrin is not required for SNX-BAR-retromer-mediated carrier formation.Journal of cell science · 2013Article
- The retromer complex - endosomal protein recycling and beyond.Journal of cell science · 2012Review
- Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism.Journal of nanobiotechnology · 2012Article
- Article
- Phosphoinositides in the mammalian endo-lysosomal network.Sub-cellular biochemistry · 2012Review
- Sorting nexins provide diversity for retromer-dependent trafficking events.Nature cell biology · 2011Review
- A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion.Nature cell biology · 2011Article
- The SNXy flavours of endosomal sorting.Nature cell biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSorting nexins (SNXs) constitute a family of proteins classified by their phosphatidylinositol (PI) binding Phox homology (PX) domain. Some members regulate intracellular trafficking. We have here investigated mechanisms underlying SNX4 mediated endosome to Golgi transport. METHODOLOGY/PRINCIPAL
findingsWe show that SNX4 forms complexes with clathrin and dynein. The interactions were inhibited by wortmannin, a PI3-kinase inhibitor, suggesting that they form when SNX4 is associated with PI(3)P on endosomes. We further localized the clathrin interacting site on SNX4 to a clathrin box variant. A short peptide containing this motif was sufficient to pull down both clathrin and dynein. Knockdown studies demonstrated that clathrin is not required for the SNX4/dynein interaction. Moreover, clathrin knockdown led to increased Golgi transport of the toxin ricin, as well as redistribution of endosomes. CONCLUSIONS/SIGNIFICANCE: We discuss the possibility of clathrin serving as a regulator of SNX4-dependent transport. Upon clathrin release, dynein may bind SNX4 and mediate retrograde movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.