Evidence map›Paper›PMID 19528829›Full record

ArticleJournal of occupational and environmental medicine2009

Bone lead and endogenous exposure in an environmentally exposed elderly population: the normative aging study.

Huiling Nie, Brisa N Sánchez, Elissa Wilker, Marc G Weisskopf, Joel Schwartz, David Sparrow, Howard Hu

Abstract read
In one paragraph

Article in Journal of occupational and environmental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. The effect of chelation on bone Pb stores in Pb poisoned children.Journal of exposure science & environmental epidemiology · 2025
    Article
  4. Heavy Metals and Trajectories of Anti-Müllerian Hormone During the Menopausal Transition.The Journal of clinical endocrinology and metabolism · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2016
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huiling NieDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA. nieh@hsph.harvard.edu
Brisa N Sánchez
Elissa Wilker
Marc G Weisskopf
Joel Schwartz
David Sparrow
Howard Hu

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMESR01ES007821 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 1998 to 2010
$4.7M
LEAD-GENE INTERACTIONS AND CONGNITIONR01ES005257 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISSKOPF, MARC G · 1991 to 2007
$4.2M
GENE-METAL INTERACTIONS AND PARKINSON'S DISEASER01ES010798 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, HOWARD · 2002 to 2006
$3.0M
IN VIVO TOTAL BODY LEAD ANALYSIS BY X-RAY FLUORESCENCER44ES003918 · NIEHS · ABIOMED, INC. · PI MILDER, FREDRIC L · 1987 to 1988
–
NIEHS NIH HHS 2R44 ES03918-02NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES005257NIEHS NIH HHS R01-ES005257NIEHS NIH HHS R01 ES007821NIEHS NIH HHS R01-ES007821NIEHS NIH HHS R01 ES010798NIEHS NIH HHS R01-ES010798
6 · The paper itself

Abstract

objectiveThe objective of this study is to investigate the mobilization of lead from bone to blood (endogenous exposure) in a large epidemiologic population.

methodsStudy subjects were 776 participants in the Normative Aging Study. The subjects had their tibia lead, patella lead, blood lead, and urinary N-telopeptide (NTx) levels measured 1 to 4 times from 1991 to 2002. Regression models were estimated to quantify the association between tibia and patella lead and blood lead. We studied nonlinearity of the association, and explored possible factors that may modify it, including age and NTx levels. RESULTS AND

conclusionsThere is significant association between bone lead and blood lead, and the association is nonlinear. The nonlinear associations between blood lead and bone lead are not significantly modified by age and NTx.

Indexed as

AdultAgedAged, 80 and overBone and BonesBostonCollagen Type IHumansLeadMaleMiddle AgedPatellaPeptidesRegression AnalysisTibiaYoung AdultCollagen Type Icollagen type I trimeric cross-linked peptideLeadPeptides

Identifiers

PMID19528829
PMCPMC3800179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.