ArticleGenetics2009
Centrosomin: a complex mix of long and short isoforms is required for centrosome function during early development in Drosophila melanogaster.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes.The Journal of cell biology · 2023Article
- BmCDK5 Affects Cell Proliferation and Cytoskeleton Morphology by Interacting with BmCNN inInsects · 2022Article
- Autoinhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects.The Journal of cell biology · 2021Article
- Analysis of insect nuclear small heat shock proteins and interacting proteins.Cell stress & chaperones · 2021Article
- Article
- Microtubule nucleation by γ-tubulin complexes and beyond.Essays in biochemistry · 2018Review
- γ-TuRC Heterogeneity Revealed by Analysis of Mozart1.Current biology : CB · 2018Article
- Assembly and regulation of γ-tubulin complexes.Open biology · 2018Review
- Rapid DNA Synthesis During EarlyGenetics · 2017Article
- A Splice Variant of Centrosomin Converts Mitochondria to Microtubule-Organizing Centers.Current biology : CB · 2017Article
- Article
- Article
- Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.Development (Cambridge, England) · 2014Article
- Probing the boundaries of orthology: the unanticipated rapid evolution of Drosophila centrosomin.Genetics · 2013Article
- Myomegalin is necessary for the formation of centrosomal and Golgi-derived microtubules.Biology open · 2013Article
- Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Centrosomin (Cnn) is a required core component in mitotic centrosomes during syncytial development and the presence of Cnn at centrosomes has become synonymous with fully functional centrosomes in Drosophila melanogaster. Previous studies of Cnn have attributed this embryonic function to a single isoform or splice variant. In this study, we present new evidence that significantly increases the complexity of cnn. Rather than a single isoform, Cnn function can be attributed to two unique classes of proteins that comprise a total of at least 10 encoded protein isoforms. We present the initial characterization of a new class of Cnn short isoforms required for centrosome function during gametogenesis and embryogenesis. We also introduce new evidence for a complex mix of Cnn isoforms present during early embryogenesis. Finally, we reexamine cnn mutations, in light of the short isoforms, and find previously overlooked differences attributable to allele-specific mutant phenotypes. This study addresses several questions surrounding Cnn function at the centrosome during embryogenesis and shows that cnn function cannot be ascribed to a single protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.