ArticleThe Journal of physiology2009
Glycinergic input of widefield, displaced amacrine cells of the mouse retina.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Changes in glycinergic neurotransmission alter mammalian retinal information processing.Frontiers in molecular neuroscience · 2025Article
- ON and OFF starburst amacrine cells are controlled by distinct cholinergic pathways.The Journal of general physiology · 2024Article
- Spatial organization of the mouse retina at single cell resolution by MERFISH.Nature communications · 2023Article
- Light responses and amacrine cell modulation of morphologically-identified retinal ganglion cells in the mouse retina.Vision research · 2023Article
- Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABAThe European journal of neuroscience · 2022Article
- Gain control by sparse, ultra-slow glycinergic synapses.Cell reports · 2022Article
- Mouse Retinal Cell Atlas: Molecular Identification of over Sixty Amacrine Cell Types.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Glycinergic and GABAergic interneurons shift the location and differentially alter the size of ganglion cell receptive field centers in the mammalian retina.Vision research · 2020Article
- A retinal circuit for the suppressed-by-contrast receptive field of a polyaxonal amacrine cell.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Principal Neurons in the Anteroventral Cochlear Nucleus Express Cell-Type Specific Glycine Receptor α Subunits.Neuroscience · 2019Article
- Defects of the Glycinergic Synapse in Zebrafish.Frontiers in molecular neuroscience · 2016Review
- Article
- Morphology and connectivity of the small bistratified A8 amacrine cell in the mouse retina.The Journal of comparative neurology · 2015Article
- GlyRα2, not GlyRα3, modulates the receptive field surround of OFF retinal ganglion cells.Visual neuroscience · 2015Article
- Response Properties of a Newly Identified Tristratified Narrow Field Amacrine Cell in the Mouse Retina.PloS one · 2015Article
- Adeno-associated virus-RNAi of GlyRα1 and characterization of its synapse-specific inhibition in OFF alpha transient retinal ganglion cells.Journal of neurophysiology · 2014Article
- ON-pathway-dominant glycinergic regulation of cholinergic amacrine cells in the mouse retina.The Journal of physiology · 2014Article
- Receptor targets of amacrine cells.Visual neuroscience · 2012Review
- Inputs underlying the ON-OFF light responses of type 2 wide-field amacrine cells in TH::GFP mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Glycinergic transmission in the Mammalian retina.Frontiers in molecular neuroscience · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycine receptors (GlyRs) of displaced amacrine cells of the mouse retina were analysed using whole cell recordings and immunocytochemical staining with subunit-specific antibodies. During the recordings the cells were filled with a fluorescent tracer and 11 different morphological types could be identified. The studies were performed in wild-type mice and in mutant mice deficient in the GlyRalpha1 (Glra1(spd-ot), 'oscillator' mouse), the GlyRalpha2 (Glra2(-/-)) and the GlyRalpha3 subunit (Glra3(-/-)). Based on their responses to the application of exogenous glycine in the retinas of wild-type and mutant mice, the cells were grouped into three major classes: group I cells (comprising the morphological types MA-S5, MA-S1, MA-S1/S5, A17, PA-S1, PA-S5 and WA-S1), group II cells (comprising the morphological types PA-S4, WA-S3 and WA-multi) and ON-starburst cells. For further analysis, spontaneous inhibitory postsynaptic currents (sIPSCs) were measured both in wild-type and mutant mouse retinas. Glycinergic sIPSCs and glycine induced currents of group I cells remained unaltered across wild-type and the three mutant mice (mean decay time constant of sIPSCs, tau approximately 25 ms). Group II cells showed glycinergic sIPSCs and glycine induced currents in wild-type, Glra1(spd-ot) and Glra3(-/-) mice (tau approximately 25 ms); however, glycinergic currents were absent in group II cells of Glra2(-/-) mice. Glycine induced currents and sIPSCs recorded from ON-starburst amacrine cells did not differ significantly between wild-type and the mutant mouse retinas (tau approximately 50-70 ms). We propose that GlyRs of group II cells are dominated by the alpha2 subunit; GlyRs of ON-starburst amacrine cells appear to be dominated by the alpha4 subunit.
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