ArticleInfection and immunity2009
Influenza A virus neuraminidase enhances meningococcal adhesion to epithelial cells through interaction with sialic acid-containing meningococcal capsules.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Risk factors for meningococcal disease in children and adolescents: a systematic review and META-analysis.European journal of pediatrics · 2020Pooled it
- Pooled it
- Is meningococcal B vaccination needed in the post-COVID-19 world?Biomedica : revista del Instituto Nacional de Salud · 2025Review
- Troubled Times, Changing Tides: A Seroprevalence Study on Meningococcal Immunity in France Between 2016 and 2024.Vaccines · 2025Article
- Review
- A Pediatric Case of Serogroup Y Meningococcal Meningitis in a 12-Year-Old Boy Combined with Respiratory Infection of Three Species of Viruses in China.Infection and drug resistance · 2025Article
- Vaccination against Community-Acquired Pneumonia in Spanish Adults: Practical Recommendations by the NeumoExperts Prevention Group.Antibiotics (Basel, Switzerland) · 2023Review
- Comparing sputum microbiota characteristics between severe and critically ill influenza patients.Frontiers in cellular and infection microbiology · 2023Article
- Co-infection of the respiratory epithelium, scene of complex functional interactions between viral, bacterial, and human neuraminidases.Frontiers in microbiology · 2023Review
- Impact of Covid-19 pandemic on pediatric meningitis incidence in central Morocco.Scientific African · 2022Article
- Impact of mandatory vaccination against serogroup C meningococci in targeted and non-targeted populations in France.NPJ vaccines · 2022Article
- Excess Invasive Meningococcal Disease Associated With Seasonal Influenza, South Africa, 2003-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Changes in InvasiveMicroorganisms · 2022Article
- The Host-Pathogen Interactions and Epicellular Lifestyle ofFrontiers in cellular and infection microbiology · 2022Review
- Risk factors for invasive meningococcal disease: a retrospective analysis of the French national public health insurance database.Human vaccines & immunotherapeutics · 2021Article
- Relationship between influenza and dengue outbreaks, and subsequent bacterial sepsis in French Guiana: A time series analysis.Journal of public health research · 2021Article
- Impact of COVID-19 pandemic and the lockdown on invasive meningococcal disease.BMC research notes · 2020Article
- Epidemiology of invasive meningococcal disease in Cyprus 2004 to 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
- Close Encounters of the Viral Kind: Cross-Kingdom Synergies at the Host-Pathogen Interface.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019Review
- Meningococcal pneumonia: a review.Pneumonia (Nathan Qld.) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The underlying mechanisms of the epidemiological association between influenza virus infections and Neisseria meningitidis invasive infections are not fully understood. Here we report that adhesion of N. meningitidis to human Hec-1-B epithelial cells is enhanced by influenza A virus (IAV) infection. A potential role of the viral neuraminidase (NA) in facilitating meningococcal adhesion to influenza virus-infected epithelial cells was examined. Expression of a recombinant IAV NA in Hec-1-B human epithelial cells increased the adhesion of strains of N. meningitidis belonging to the sialic acid-containing capsular serogroups B, C, and W135 but not to the mannosamine phosphate-containing capsular serogroup A. Adhesion enhancement was not observed with an inactive NA mutant or in the presence of an NA inhibitor (zanamivir). Furthermore, purified IAV NA was shown to cleave sialic acid-containing capsular polysaccharides of N. meningitidis. On the whole, our findings suggest that a direct interaction between the NA of IAV and the capsule of N. meningitidis enhances bacterial adhesion to cultured epithelial cells, most likely through cleavage of capsular sialic acid-containing polysaccharides. A better understanding of the association between IAV and invasive meningococcal infections should help to set up improved control strategies against these seasonal dual viral-bacterial infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.