ArticleJournal of medical microbiology2009
Distribution of the leptospiral immunoglobulin-like (lig) genes in pathogenic Leptospira species and application of ligB to typing leptospiral isolates.
Article in Journal of medical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- TheInfection and immunity · 2026Article
- Identification of virulence genes and clade-specific markers through pan-genomic analysis of Leptospira.BMC microbiology · 2025Article
- Immunoinformatic Study of Recombinant LigA/BCon1-5 Antigen and Evaluation of Its Diagnostic Potential in Primary and Secondary Binding Tests for Serodiagnosis of Porcine Leptospirosis.Pathogens (Basel, Switzerland) · 2021Article
- Leptospiral Infection, Pathogenesis and Its Diagnosis-A Review.Pathogens (Basel, Switzerland) · 2021Review
- An Improved Enzyme-Linked Immunoassay for the Detection ofThe American journal of tropical medicine and hygiene · 2018Article
- LeptoDB: an integrated database of genomics and proteomics resource of Leptospira.Database : the journal of biological databases and curation · 2018Article
- Molecular typing of Leptospira interrogans serovar Hardjo isolates from leptospirosis outbreaks in Brazilian livestock.BMC veterinary research · 2017Article
- LigB subunit vaccine confers sterile immunity against challenge in the hamster model of leptospirosis.PLoS neglected tropical diseases · 2017Article
- A Universal Vaccine against Leptospirosis: Are We Going in the Right Direction?Frontiers in immunology · 2017Article
- What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira.PLoS neglected tropical diseases · 2016Article
- Control of Gene Expression in Leptospira spp. by Transcription Activator-Like Effectors Demonstrates a Potential Role for LigA and LigB in Leptospira interrogans Virulence.Applied and environmental microbiology · 2015Article
- Protective Immunity and Reduced Renal Colonization Induced by Vaccines Containing Recombinant Leptospira interrogans Outer Membrane Proteins and Flagellin Adjuvant.Clinical and vaccine immunology : CVI · 2015Article
- Use of a New High Resolution Melting Method for Genotyping Pathogenic Leptospira spp.PloS one · 2015Article
- Diagnostic Accuracy of Recombinant Immunoglobulin-like Protein A-Based IgM ELISA for the Early Diagnosis of Leptospirosis in the Philippines.PLoS neglected tropical diseases · 2015Article
- Isolation of a Seawater Tolerant Leptospira spp. from a Southern Right Whale (Eubalaena australis).PloS one · 2015Article
- Genotypes of pathogenic Leptospira spp isolated from rodents in Argentina.Memorias do Instituto Oswaldo Cruz · 2014Article
- Characterization of leptospira isolates from animals and humans: phylogenetic analysis identifies the prevalence of intermediate species in India.SpringerPlus · 2013Article
- Comparison of two multilocus sequence based genotyping schemes for Leptospira species.PLoS neglected tropical diseases · 2011Article
- Development of transcriptional fusions to assess Leptospira interrogans promoter activity.PloS one · 2011Article
- Rapid Leptospira identification by direct sequencing of the diagnostic PCR products in New Caledonia.BMC microbiology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
The family of leptospiral immunoglobulin-like (lig) genes comprises ligA, ligB and ligC. This study used PCR to demonstrate the presence of lig genes among serovars from a collection of leptospiral strains and clinical isolates. Whilst ligA and ligC appeared to be present in a limited number of pathogenic serovars, the ligB gene was distributed ubiquitously among all pathogenic strains. None of the lig genes were detected among intermediate or saprophytic Leptospira species. It was also shown that, similar to the previously characterized secY gene, a short specific PCR fragment of ligB could be used to correctly identify pathogenic Leptospira species. These findings demonstrate that ligB is widely present among pathogenic strains and may be useful for their reliable identification and classification.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.