Evidence map›Paper›PMID 19528175›Full record

ArticleJournal of medical microbiology2009

In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms.

Robin K Pettit, Christine A Weber, Stacey B Lawrence, George R Pettit, Melissa J Kean, Gary D Cage

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Drug combinations targeting antibiotic resistance.npj antimicrobials and resistance · 2024
    Review
  2. Promising Therapeutic Strategies Against Microbial Biofilm Challenges.Frontiers in cellular and infection microbiology · 2020
    Review
  3. Journal of fungi (Basel, Switzerland) · 2019
    Review
  4. Hyperoside inhibits biofilm formation ofExperimental and therapeutic medicine · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robin K PettitCancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
Christine A WeberCancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
Stacey B LawrenceCancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
George R PettitCancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
Melissa J KeanCancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
Gary D CagePhoenix Children's Hospital, Phoenix, AZ 85016, USA.
Arizona State University · USPhoenix Children's Hospital · US

Funding

Molecular Target Focused Discovery of Anticancer DrugsR01CA090441 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI PETTIT, GEORGE R · 2001 to 2010
$4.8M
Molecular Target Focused Discovery of Anticancer DrugsR56CA090441 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI PETTIT, GEORGE R · 2007 to 2007
$498k
NCI NIH HHS 2R56 CA090441 -06A1NCI NIH HHS 5R01 CA090441 -07NCI NIH HHS R01 CA090441NCI NIH HHS R01 CA90441-01 -05NCI NIH HHS R56 CA090441
6 · The paper itself

Abstract

The alarming spread of multiple drug resistance in Staphylococcus aureus, combined with the frequent occurrence of S. aureus and Staphylococcus epidermidis in biofilm-type infections, indicates a growing need for new therapies. The experimental steroidal amide anprocide [3beta-acetoxy-17beta-(l-prolyl)amino-5alpha-androstane] significantly reduced c.f.u. ml(-1) per suture (P <0.0001) in a murine model of topical S. aureus infection. In chequerboard assays with planktonic-grown S. aureus and S. epidermidis, anprocide was synergistic with bacitracin, oxacillin, clindamycin or ceftriaxone. Anprocide was also synergistic in combination with bacitracin or oxacillin against some isolates of biofilm-grown S. aureus and S. epidermidis.

Indexed as

BiofilmsAndrostanesAnimalsAnti-Bacterial AgentsDose-Response Relationship, DrugMiceProlineStaphylococcal Skin InfectionsStaphylococcus aureusStaphylococcus epidermidis3-acetoxy-17-prolylaminoandrostaneAndrostanesAnti-Bacterial AgentsProline

Identifiers

PMID19528175
PMCPMC2887550
OpenAlexW2137142097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.