Evidence map›Paper›PMID 19527884›Full record

ReviewCell host & microbe2009

Common themes in the design and function of bacterial effectors.

Jorge E Galán

Abstract readReview
In one paragraph

Review in Cell host & microbe, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers.

0numbers the graph read from it
0cells of the map it votes in
194citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

194 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. International journal of molecular sciences · 2026
    Article
  5. mBio · 2026
    Article
  6. Review
  7. Strain-specific persistence ofJournal of medical microbiology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Atomic Structure and Phospholipid Binding Properties of thebioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Experimental Approaches to Visualize Effector Protein Translocation During Host-Pathogen Interactions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  14. VopX, a novelmBio · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

134 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Jorge E GalánSection of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA. jorge.galan@yale.edu

Funding

Host Cell Signaling Pathways Induced By SalmonellaR01AI055472 · NIAID · YALE UNIVERSITY · PI Jorge E Galan · 2003 to 2026
$13.2M
MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR37AI030492 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2000 to 2024
$10.1M
MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR01AI030492 · NIAID · YALE UNIVERSITY · PI Jorge E Galan · 1995 to 2026
$3.1M
The type III secretion effector protein interactomeR21AI072516 · NIAID · YALE UNIVERSITY · PI GALAN, JORGE E · 2007 to 2008
$451k
MOLECULAR GENETIC ANALYSIS OF SALMONELLA CELL INVASIONR29AI030492 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI GALAN, JORGE E · 1991 to 1995
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NIAID NIH HHS AI055472NIAID NIH HHS AI072516NIAID NIH HHS AI30492NIAID NIH HHS R01 AI030492NIAID NIH HHS R01 AI055472NIAID NIH HHS R21 AI072516NIAID NIH HHS R37 AI030492
6 · The paper itself

Abstract

Central to the biology of many pathogenic bacteria are a number of specialized machines, known as type III, type IV, or type VI protein secretion systems. These machines have specifically evolved to deliver bacterial effector proteins into host cells with the capacity to modulate a variety of cellular functions. The identification of the biochemical activities of many effector proteins, coupled with a better understanding of their potential contribution to pathogenesis, has revealed common themes in the evolutionary design and function of these remarkable bacterial proteins.

Indexed as

Bacterial Physiological PhenomenaHost-Pathogen InteractionsBacteriaBacterial ProteinsModels, MolecularVirulence FactorsBacterial ProteinsVirulence Factors

Identifiers

PMID19527884
PMCPMC2729653

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.