ArticleAnaerobe2010
Lethal toxin is a critical determinant of rapid mortality in rodent models of Clostridium sordellii endometritis.
Article in Anaerobe, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Detection and molecular characterization of Clostridium perfringens, Paeniclostridium sordellii and Clostridium septicum from lambs and goat kids with hemorrhagic abomasitis in Turkey.BMC veterinary research · 2023Article
- Paeniclostridium sordellii uterine infection is dependent on the estrous cycle.PLoS pathogens · 2022Article
- Persistent bacteremia and psoas abscess caused by a lethal toxin-deficient Paeniclostridiumsordellii.Anaerobe · 2022Article
- Categorizing Sequences of Concern by Function To Better Assess Mechanisms of Microbial Pathogenesis.Infection and immunity · 2022Review
- Prevalence and Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2021Article
- Large Clostridial Toxins: Mechanisms and Roles in Disease.Microbiology and molecular biology reviews : MMBR · 2021Review
- Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL.Cell host & microbe · 2020Article
- Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract.PLoS pathogens · 2018Article
- Article
- Survival from Clostridium toxic shock syndrome: Case report and review of the literature.International journal of surgery case reports · 2018Article
- Non-lethal Clostridium sordellii bacteraemia in an immunocompromised patient with pleomorphic sarcoma.BMJ case reports · 2016Article
- Vaginal and Rectal Clostridium sordellii and Clostridium perfringens Presence Among Women in the United States.Obstetrics and gynecology · 2016Observational
- Clostridium sordellii genome analysis reveals plasmid localized toxin genes encoded within pathogenicity loci.BMC genomics · 2015Article
- Identification and characterization of Clostridium sordellii toxin gene regulator.Journal of bacteriology · 2013Article
- Gynecologic clostridial toxic shock in women of reproductive age.Current infectious disease reports · 2011Article
- Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremia.Anaerobe · 2011Article
- TcsL is an essential virulence factor in Clostridium sordellii ATCC 9714.Infection and immunity · 2011Article
- The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Comparative analysis of the extracellular proteomes of two Clostridium sordellii strains exhibiting contrasting virulence.Anaerobe · 2010Article
- Pseudo-outbreak of Clostridium sordellii infection following probable cross-contamination in a hospital clinical microbiology laboratory.Infection control and hospital epidemiology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The toxigenic anaerobe Clostridium sordellii is an uncommon but highly lethal cause of human infection and toxic shock syndrome, yet few studies have addressed its pathogenetic mechanisms. To better characterize the microbial determinants of rapid death from infection both in vitro and in vivo studies were performed to compare a clinical strain of C. sordellii (DA-108), isolated from a patient who survived a disseminated infection unaccompanied by toxic shock syndrome, to a virulent reference strain (ATCC9714). Rodent models of endometrial and peritoneal infection with C. sordellii ATCC9714 were rapidly lethal, while infections with DA-108 were not. Extensive genetic and functional comparisons of virulence factor and toxin expression between these two bacterial strains yielded many similarities, with the noted exception that strain DA-108 lacked the tcsL gene, which encodes the large clostridial glucosyltransferase enzyme lethal toxin (TcsL). The targeted removal by immunoprecipitation of TcsL protected animals from death following injection of crude culture supernatants from strain ATCC9714. Injections of a monoclonal anti-TcsL IgG protected animals from death during C. sordellii ATCC9714 infection, suggesting that such an approach might improve the treatment of patients with C. sordellii-induced toxic shock syndrome.
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