Evidence map›Paper›PMID 19527704›Full record

ReviewDevelopmental biology2010

Nucleosome positioning: how is it established, and why does it matter?

Marta Radman-Livaja, Oliver J Rando

Open access · greenAbstract readReview
In one paragraph

Review in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 306 citations in OpenAlex.

  1. Machine learning reveals sequence and genomic context features underlyingbioRxiv : the preprint server for biology · 2026
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  15. Visualizing the 4D Impact of Gold Nanoparticles on DNA.International journal of molecular sciences · 2023
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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marta Radman-LivajaDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Oliver J Rando
University of Massachusetts Chan Medical School · US

Funding

Genomic analysis of histone replacement dynamics in yeastR01GM079205 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RANDO, OLIVER J · 2008 to 2016
$3.3M
NIGMS NIH HHS R01 GM079205
6 · The paper itself

Abstract

Packaging of eukaryotic genomes into chromatin affects every process that occurs on DNA. The positioning of nucleosomes on underlying DNA plays a key role in the regulation of these processes, as the nucleosome occludes underlying DNA sequences. Here, we review the literature on mapping nucleosome positions in various organisms, and discuss how nucleosome positions are established, what effect nucleosome positioning has on control of gene expression, and touch on the correlations between chromatin packaging, sequence evolution, and the evolution of gene expression programs.

Indexed as

Gene Expression RegulationBase SequenceChromatinChromatin Assembly and DisassemblyEpigenesis, GeneticEvolution, MolecularGenetic VariationGenomicsNuclear ProteinsNucleosomesTranscription, GeneticChromatinNuclear ProteinsNucleosomes

Identifiers

PMID19527704
PMCPMC2830277
OpenAlexW1997519837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.