ArticleEpidemiology and infection2009
Meta-analysis of a polymorphic surface glycoprotein of the parasitic protozoa Cryptosporidium parvum and Cryptosporidium hominis.
Article in Epidemiology and infection, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Prevalence ofFrontiers in cellular and infection microbiology · 2021Pooled it
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- The Long and Short of Next Generation Sequencing forFrontiers in cellular and infection microbiology · 2022Review
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- Comparative genetic diversity ofParasitology · 2020Article
- Evolutionary processes in populations of Cryptosporidium inferred from gp60 sequence data.Parasitology research · 2017Article
- Local and global genetic diversity of protozoan parasites: Spatial distribution of Cryptosporidium and Giardia genotypes.PLoS neglected tropical diseases · 2017Observational
- Hypothesis: Cryptosporidium genetic diversity mirrors national disease notification rate.Parasites & vectors · 2015Article
- Multiple Cryptosporidium parvum subtypes detected in a unique isolate of a Chilean neonatal calf with diarrhea.Parasitology research · 2015Article
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- Subtyping Cryptosporidium ubiquitum,a zoonotic pathogen emerging in humans.Emerging infectious diseases · 2014Article
- Cryptosporidium pathogenicity and virulence.Clinical microbiology reviews · 2013Review
- Comparative genome analysis of two Cryptosporidium parvum isolates with different host range.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Article
- Multilocus fragment typing and genetic structure of Cryptosporidium parvum Isolates from diarrheic preweaned calves in Spain.Applied and environmental microbiology · 2011Article
- Zoonotic linkage and variation in Cryptosporidium parvum from patients in the United Kingdom.Parasitology research · 2011Article
- Comparison of single- and multilocus genetic diversity in the protozoan parasites Cryptosporidium parvum and C. hominis.Applied and environmental microbiology · 2010Article
- Multi-locus analysis of human infective Cryptosporidium species and subtypes using ten novel genetic loci.BMC microbiology · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Due to its extensive polymorphism, a partial sequence of the Cryptosporidium surface glycoprotein gene gp60 has been frequently used as a genetic marker. I explored the global diversity of this protein, and compared its sequence diversity in Cryptosporidium parvum and Cryptosporidium hominis. In marked contrast to the geographical partition of C. parvum and C. hominis multi-locus genotypes, gp60 allelic groups showed no evidence of segregating in space, or of differing with respect to geographical diversity. Globally, genetic diversity of C. hominis gp60 exceeded that of C. parvum. Within C. parvum, gp60 alleles originating from human isolates were more diverse than those infecting ruminants. Phylogenetic analysis grouped gp60 sequences into a small number of relatively homogenous allelic groups, with only a small number of alleles having evolved independently. With the notable exception of a group of alleles restricted to humans, C. parvum alleles are found in ruminants and humans.
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Registered trials
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