ArticleAntioxidants & redox signaling2009
Iron and menopause: does increased iron affect the health of postmenopausal women?
Article in Antioxidants & redox signaling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03512743 (A Observational Study to Investigate the Relationship of Levels of Serum Ferritin, Bone Mineral Density and Bone Metabolism in Chinese Healthy Postmenopausal Women), which is not on this map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Observational Study to Investigate the Relationship of Levels of Serum Ferritin, Bone Mineral Density and Bone Metabolism in Chinese Healthy Postmenopausal Women
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis.BMC cancer · 2019Pooled it
- Is Higher Consumption of Animal Flesh Foods Associated with Better Iron Status among Adults in Developed Countries? A Systematic Review.Nutrients · 2016Pooled it
- The statin-iron nexus: anti-inflammatory intervention for arterial disease prevention.American journal of public health · 2013Trial
- Placental Iron Homeostasis: Navigating the Delicate Balance Between Transport and Ferroptosis.International journal of molecular sciences · 2026Review
- Population-scale reconstruction of menopause dynamics reveals a physiological cliff at the final menstrual period.Nature medicine · 2026Article
- The role of iron in driving sex-biased differences in cancer.Cancer metastasis reviews · 2026Review
- Article
- A narrative review on critical roles of iron levels in skin tone, aging, and photoaging.International journal of women's dermatology · 2026Review
- Macrophage iron overload promotes osteoporosis via Cxcl3- and Cxcl7-mediated paracrine signaling in ovariectomized mice.Journal of orthopaedic translation · 2026Article
- Impact of long-term fasting on liver and abdominal adipose tissues monitored by quantitative chemical-shift encoded MRI.Frontiers in nutrition · 2026Article
- Sex differences in iron stores and associations of body iron with cardiovascular risk factors in the middle-aged general population.Frontiers in endocrinology · 2026Article
- Oviductus Ranae alleviates D-galactose-induced ovarian aging by inhibiting ferroptosis and regulating the GPX4/ACSL4 pathway.Journal of ovarian research · 2025Article
- Accelerated increase in ferritin levels during menopausal transition as a marker of metabolic health.Scientific reports · 2025Article
- Myocardial transcriptomic and proteomic landscapes across the menopausal continuum in a murine model of chemically induced accelerated ovarian failure.Physiological genomics · 2025Article
- Oxidative Stress, Parity History, and Remnant Follicles in the Aged Ovary: Insights on Ovarian Cancer Risk and Protection.Antioxidants (Basel, Switzerland) · 2025Review
- Assessing the effects of menopause and obesity on matriptase-2 and neurokinin B concentrations: A cross-sectional study.Journal of medical biochemistry · 2025Article
- Cognitive Function in Peri- and Postmenopausal Women: Implications for Considering Iron Supplementation.Nutrients · 2025Review
- Dysregulation of miR-106a-5p/PTEN axis associated with progression and diagnostic of postmenopausal osteoporosis.Journal of orthopaedic surgery and research · 2025Article
- Deferasirox improved iron homeostasis and hematopoiesis in ovariectomized rats with iron accumulation.Scientific reports · 2025Article
- Threshold-effect of ferritin levels with pathoglycemia in Chinese adults: a cross-sectional study based on China health and nutrition survey data.BMC endocrine disorders · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Estrogen deficiency has been regarded as the main causative factor in menopausal symptoms and diseases. Here, we show that although estrogen decreases by 90%, a concurrent but inverse change occurs in iron levels during menopausal transition. For example, levels of serum ferritin are increased by two- to threefold from before menopause to after menopause. This observation has led us to hypothesize that, in addition to estrogen deficiency, increased iron as a result of menopause could be a risk factor affecting the health of postmenopausal women. Further studies on iron and menopause are clinically relevant and may provide novel therapeutic treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.