ArticleThe Journal of infectious diseases2009
Esterase D is essential for protection of Neisseria gonorrhoeae against nitrosative stress and for bacterial growth during interaction with cervical epithelial cells.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- The Moraxella catarrhalis AdhC-FghA system is important for formaldehyde detoxification and protection against pulmonary clearance.Medical microbiology and immunology · 2024Article
- Copper management strategies in obligate bacterial symbionts: balancing cost and benefit.Emerging topics in life sciences · 2024Article
- Applying genome-wide CRISPR to identify known and novel genes and pathways that modulate formaldehyde toxicity.Chemosphere · 2021Article
- Formaldehyde Stress Responses in Bacterial Pathogens.Frontiers in microbiology · 2016Review
- Identification of genes involved in Neisseria meningitidis colonization.Infection and immunity · 2013Article
- Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.Journal of proteome research · 2012Article
- Phenotypic characterization of a copA mutant of Neisseria gonorrhoeae identifies a link between copper and nitrosative stress.Infection and immunity · 2012Article
- The role of catalase in gonococcal resistance to peroxynitrite.Microbiology (Reading, England) · 2012Article
- Deep sequencing-based analysis of the anaerobic stimulon in Neisseria gonorrhoeae.BMC genomics · 2011Article
- The Composition and Metabolic Phenotype of Neisseria gonorrhoeae Biofilms.Frontiers in microbiology · 2011Article
- Anaerobic metabolism occurs in the substratum of gonococcal biofilms and may be sustained in part by nitric oxide.Infection and immunity · 2010Article
- Neisseria gonorrhoeae survival during primary human cervical epithelial cell infection requires nitric oxide and is augmented by progesterone.Infection and immunity · 2010Article
- aes, the gene encoding the esterase B in Escherichia coli, is a powerful phylogenetic marker of the species.BMC microbiology · 2009Article
- A periplasmic thioredoxin-like protein plays a role in defense against oxidative stress in Neisseria gonorrhoeae.Infection and immunity · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
estD encodes a carboxylic ester hydrolase and is part of the NmlR regulon in Neisseria gonorrhoeae. An estD mutant was found to be susceptible to nitrite and to S-nitrosoglutathione. This mutant was also unable to infect and survive within human cervical epithelial cells, and it showed reduced ability to form a biofilm on these cells. We conclude that esterase D is an integral part of the nitrosative stress defense system of N. gonorrhoeae and that it has potential importance in pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.