ArticleNeurotoxicity research2009
The janus face of resveratrol in astroglial cells.
Article in Neurotoxicity research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- Melatonin Modulates Astrocyte Inflammatory Response and Nrf2/SIRT1 Signaling Pathways in Adult Rat Cortical Cultures.Biomedicines · 2025Article
- Evaluation of the effects of the Zika Virus-Immunoglobulin GJournal of neurovirology · 2024Article
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- Lipopolysaccharide Induces Gliotoxicity in Hippocampal Astrocytes from Aged Rats: Insights About the Glioprotective Roles of Resveratrol.Molecular neurobiology · 2022Article
- Calcitonin gene-related peptide induces the histone H3 lysine 9 acetylation in astrocytes associated with neuroinflammation in rats with neuropathic pain.CNS neuroscience & therapeutics · 2021Article
- Zika virus exposure affects neuron-glia communication in the hippocampal slices of adult rats.Scientific reports · 2020Article
- Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro.Neurochemical research · 2020Article
- AST-120 Reduces Neuroinflammation Induced by Indoxyl Sulfate in Glial Cells.Journal of clinical medicine · 2018Article
- Effect of a trans fatty acid-enriched diet on mitochondrial, inflammatory, and oxidative stress parameters in the cortex and hippocampus of Wistar rats.European journal of nutrition · 2018Article
- Homocysteine Induces Glial Reactivity in Adult Rat Astrocyte Cultures.Molecular neurobiology · 2018Article
- Higher Vulnerability of Menadione-Exposed Cortical Astrocytes of Glutaryl-CoA Dehydrogenase Deficient Mice to Oxidative Stress, Mitochondrial Dysfunction, and Cell Death: Implications for the Neurodegeneration in Glutaric Aciduria Type I.Molecular neurobiology · 2017Article
- Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia.Frontiers in pharmacology · 2017Article
- Induction of a Proinflammatory Response in Cortical Astrocytes by the Major Metabolites Accumulating in HMG-CoA Lyase Deficiency: the Role of ERK Signaling Pathway in Cytokine Release.Molecular neurobiology · 2016Article
- Gap Junction Intercellular Communication Mediates Ammonia-Induced Neurotoxicity.Neurotoxicity research · 2016Article
- Resveratrol Protects Hippocampal Astrocytes Against LPS-Induced Neurotoxicity Through HO-1, p38 and ERK Pathways.Neurochemical research · 2015Article
- Gliopreventive effects of guanosine against glucose deprivation in vitro.Purinergic signalling · 2013Article
- Resveratrol protects C6 astrocyte cell line against hydrogen peroxide-induced oxidative stress through heme oxygenase 1.PloS one · 2013Article
- Characterization of adult rat astrocyte cultures.PloS one · 2013Article
- Treadmill exercise induces hippocampal astroglial alterations in rats.Neural plasticity · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astroglial cells are key modulators of neuropathology events. Resveratrol, a redox-active compound present in grapes and wine, has a wide range of biological effects. The aim of this study was to investigate whether resveratrol is able to prevent hydrogen peroxide (H(2)O(2))-induced oxidative damage in C6 astroglial cells. We found that following a short oxidative insult (Model I-1 mM H(2)O(2)/30 min), resveratrol increased glutamate uptake (60%), glutamine synthetase (GS) (139%), glutathione (GSH) (120%), and S100B secretion (24%); and attenuated DCFH oxidation (34%) as compared to H(2)O(2) values. Under less intense (0.1 mM H(2)O(2)), but lasting (6 h) insult (Model II), resveratrol had an opposite effect, potentiating the H(2)O(2)-induced decrease in glutamate uptake (from 34 to 63%), in GS (from 22 to 50%), in GSH (from 22 to 54%), and also potentiating DCFH oxidation (from 24 to 38%). The transcription factor, NF-kappaB, was activated in both models. Cell morphology alterations were also observed in the presence of H(2)O(2) with process-bearing cells, accompanied by cell body retraction and actin reorganization. This effect was not prevented by resveratrol, but was prevented by lysophosphatidic acid (LPA), a specific upstream positive regulator of Rho A. In summary, these findings showed that resveratrol, a redox-active compound, was able to modulate important neurotrophic function of astroglial cells under different oxidative conditions.
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