ArticleEuropean journal of nuclear medicine and molecular imaging2009
Assessment of the arterial input function for estimation of coronary flow reserve by single photon emission computed tomography: comparison of two different approaches.
Article in European journal of nuclear medicine and molecular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Quantification of Myocardial Perfusion Reserve Using Dynamic SPECT Imaging in Humans: A Feasibility Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Trial
- SPECT measurements of myocardial blood flow and flow reserve: from development to implementation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- First validation of myocardial flow reserve assessed by dynamicEuropean journal of nuclear medicine and molecular imaging · 2018Article
- Review: comparison of PET rubidium-82 with conventional SPECT myocardial perfusion imaging.Clinical physiology and functional imaging · 2014Review
- Incremental prognostic value of coronary flow reserve assessed with single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- Noninvasive quantification of coronary endothelial function by SPECT imaging in children with a history of Kawasaki disease.European journal of nuclear medicine and molecular imaging · 2010Article
- Optimization of flow reserve measurement using SPECT technology to evaluate the determinants of coronary microvascular dysfunction in diabetes.European journal of nuclear medicine and molecular imaging · 2010Article
- Advances in quantitative assessment of myocardial blood flow and coronary reserve.European journal of nuclear medicine and molecular imaging · 2009Article
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Authors and funding
5 authors.
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Abstract
purposeAttempts to estimate coronary flow reserve (CFR) with single photon emission computed tomography (SPECT) tracers have been recently made. We compared two different methods for the estimation of CFR by SPECT imaging.
methodsFourteen patients with coronary artery disease underwent dipyridamole 99mTc-sestamibi SPECT and intracoronary Doppler within 5 days. Myocardial blood flow (MBF) was estimated by measurement of first transit counts in the right pulmonary artery (PA) and left ventricular (LV) chamber, and myocardial counts from SPECT images. Estimated CFR was expressed as the ratio of stress MBF to rest MBF.
resultsRest and stress MBF obtained using first transit counts from PA were higher compared to that from LV chamber (rest: 1.05 ± 0.38 vs 0.87 ± 0.34 counts/pixel per s, respectively, p < 0.01 and stress: 1.34 ± 0.45 vs 0.91 ± 0.20 counts/pixel per s, respectively, p < 0.05). In the study vessels, CFR by Doppler was 1.39 ± 0.42, and SPECT CFR obtained using first transit counts from PA and LV chamber were 1.36 ± 0.43 and 1.16 ± 0.39, respectively (p across categories NS). A significant relationship between SPECT CFR obtained using first transit counts from PA and CFR by Doppler was found (r = 0.85, p < 0.001). No relationship between SPECT CFR obtained using first transit counts from LV chamber and CFR by intracoronary Doppler was OBSERVED (R = 0.43, P = NS).
conclusionSPECT-estimated CFR obtained using first transit counts from right PA is more accurate and correlates better with the results of intracoronary Doppler than estimated CFR obtained using arterial input function from LV chamber.
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