ArticleThe open neuroimaging journal2008
Unidirectional Influx and Net Accumulation of PIB.
Article in The open neuroimaging journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Longitudinal evaluation of surrogates of regional cerebral blood flow computed from dynamic amyloid PET imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Agreement between early-phase amyloid-PET and pulsed arterial spin labeling in a memory clinic cohort.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Simultaneous assessment of blood flow and myelin content in the brain white matter with dynamic [11 C]PiB PET: a test-retest study in healthy controls.EJNMMI research · 2024Article
- Early-Frame [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Generation of ConventionalMedicina (Kaunas, Lithuania) · 2023Article
- Measurement of Cerebral Perfusion Indices from the Early Phase of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer's disease.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022Article
- Dynamic Amyloid PET: Relationships toJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Identifying Mild Alzheimer's Disease With First 30-MinFrontiers in aging neuroscience · 2022Article
- Comparison of early F-18 Florbetaben PET/CT to Tc-99m ECD SPECT using voxel, regional, and network analysis.Scientific reports · 2021Article
- Quantification ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Multimodal analysis using [EJNMMI research · 2020Article
- Improved beta-amyloid PET reproducibility using two-phase acquisition and grey matter delineation.European journal of nuclear medicine and molecular imaging · 2019Article
- Relative cerebral flow from dynamic PIB scans as an alternative for FDG scans in Alzheimer's disease PET studies.PloS one · 2019Article
- Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Comparability of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Evaluation of early-phase [NeuroImage. Clinical · 2017Article
- Early [(18)F]florbetaben and [(11)C]PiB PET images are a surrogate biomarker of neuronal injury in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2016Article
- Dual-phase amyloid PET: hitting two birds with one stone.European journal of nuclear medicine and molecular imaging · 2016Article
- Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The compound {N-methyl-[(11)C]}2-(4'-methylaminophenyl)-6-hydroxybenzothiazole, "PIB", measured by positron emission tomography, has been demonstrated to image brain beta-amyloid deposition in Alzheimer's disease (AD). In the present study the benefit of measuring the PIB accumulation rate together with the unidirectional influx of PIB into the brain was investigated in healthy control subjects and patients with AD. In a monkey changes in the influx rate constant K(1) of PIB closely followed changes in CBF, caused by alteration of Pa(CO2). In addition, K(1) was high both in the monkey and in humans, suggesting that this parameter reflects CBF. Most AD patients studied showed clearly higher accumulation rate for PIB than the controls in cortical brain areas, while a few patients showed as low accumulation as the controls. K(1) did not correlate with the accumulation rate, indicating that K(1) for PIB provides extra information besides the accumulation rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.