ArticleEukaryotic cell2009
Roles of the glyoxylate and methylcitrate cycles in sexual development and virulence in the cereal pathogen Gibberella zeae.
Article in Eukaryotic cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 69 citations in OpenAlex.
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- Oxaloacetate anaplerosis differently contributes to pathogenicity in plant pathogenic fungi Fusarium graminearum and F. oxysporum.PLoS pathogens · 2024Article
- Functional Analysis of Genes Specifically Expressed during Aerial Hyphae Collapse as a Potential Signal for Perithecium Formation Induction in Fusarium graminearum.The plant pathology journal · 2024Article
- The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi.Molecules (Basel, Switzerland) · 2023Review
- AoMae1 Regulates Hyphal Fusion, Lipid Droplet Accumulation, Conidiation, and Trap Formation inJournal of fungi (Basel, Switzerland) · 2023Article
- Infectivity and stress tolerance traits affect community assembly of plant pathogenic fungi.Frontiers in microbiology · 2023Article
- The essential role of fungal peroxisomes in plant infection.Molecular plant pathology · 2022Review
- Genome-guided comparativeFrontiers in plant science · 2022Article
- NADPH Oxidase Gene,Frontiers in microbiology · 2022Review
- EngineeringJournal of fungi (Basel, Switzerland) · 2021Article
- Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities ofMolecules (Basel, Switzerland) · 2021Article
- Opposing functions of Fng1 and the Rpd3 HDAC complex in H4 acetylation in Fusarium graminearum.PLoS genetics · 2020Article
- Survival Factor GeneThe plant pathology journal · 2019Article
- Involvement of the two L-lactate dehydrogenase in development and pathogenicity in Fusarium graminearum.Current genetics · 2019Article
- Novel Fungal Pathogenicity and Leaf Defense Strategies Are Revealed by Simultaneous Transcriptome Analysis ofFrontiers in plant science · 2018Article
- Large-scale molecular genetic analysis in plant-pathogenic fungi: a decade of genome-wide functional analysis.Molecular plant pathology · 2017Review
- Chemosensitization ofFrontiers in plant science · 2017Article
- Multiple roles of a putative vacuolar protein sorting associated protein 74, FgVPS74, in the cereal pathogen Fusarium graminearum.Journal of microbiology (Seoul, Korea) · 2015Article
- Candida albicans utilizes a modified β-oxidation pathway for the degradation of toxic propionyl-CoA.The Journal of biological chemistry · 2014Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glyoxylate and methylcitrate cycles are involved in the metabolism of two- or three-carbon compounds in fungi. To elucidate the role(s) of these pathways in Gibberella zeae, which causes head blight in cereal crops, we focused on the functions of G. zeae orthologs (GzICL1 and GzMCL1) of the genes that encode isocitrate lyase (ICL) and methylisocitrate lyase (MCL), respectively, key enzymes in each cycle. The deletion of GzICL1 (DeltaGzICL1) caused defects in growth on acetate and in perithecium (sexual fruiting body) formation but not in virulence on barley and wheat, indicating that GzICL1 acts as the ICL of the glyoxylate cycle and is essential for self-fertility in G. zeae. In contrast, the DeltaGzMCL1 strains failed to grow on propionate but exhibited no major changes in other traits, suggesting that GzMCL1 is required for the methylcitrate cycle in G. zeae. Interestingly, double deletion of both GzICL1 and GzMCL1 caused significantly reduced virulence on host plants, indicating that both GzICL1 and GzMCL1 have redundant functions for plant infection in G. zeae. Thus, both GzICL1 and GzMCL1 may play important roles in determining major mycological and pathological traits of G. zeae by participating in different metabolic pathways for the use of fatty acids.
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