Tight junctions, but not too tight: fine control of lung permeability by claudins.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed.

1. A Pseudomonas aeruginosa quorum-sensing inducer controls lung permeability in establishing chronic infection via EGFR.Nature communications · 2025
   Article
2. BECLIN-1/BECN1 at the barrier: a gatekeeper of epithelial and endothelial homeostasis.Autophagy reports · 2025
   Review
3. Distinct Mechanisms of Human Retinal Endothelial Barrier Modulation In Vitro by Mediators of Diabetes and Uveitis.Life (Basel, Switzerland) · 2021
   Article
4. Characteristics of Passive Solute Transport across Primary Rat Alveolar Epithelial Cell Monolayers.Membranes · 2021
   Article
5. Enhancing Extracellular Adenosine Levels Restores Barrier Function in Acute Lung Injury Through Expression of Focal Adhesion Proteins.Frontiers in molecular biosciences · 2021
   Article
6. Non-invasive and real-time measurement of microvascular barrier in intact lungs.Biomaterials · 2019
   Article
7. A feasibility study into adenosine triphosphate measurement in exhaled breath condensate: a potential bedside method to monitor alveolar deformation.Purinergic signalling · 2018
   Observational
8. Tight junctions in pulmonary epithelia during lung inflammation.Pflugers Archiv : European journal of physiology · 2017
   Review
9. The apical junctional complex in respiratory diseases.Chonnam medical journal · 2014
   Review
10. Protein kinase D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1.The Journal of biological chemistry · 2013
    Article
11. The degradation of airway tight junction protein under acidic conditions is probably mediated by transient receptor potential vanilloid 1 receptor.Bioscience reports · 2013
    Article
12. Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system.American journal of physiology. Lung cellular and molecular physiology · 2013
    Article
13. Oxidative stress mediates the disruption of airway epithelial tight junctions through a TRPM2-PLCγ1-PKCα signaling pathway.International journal of molecular sciences · 2013
    Article
14. Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.Free radical biology & medicine · 2012
    Article
15. Claudins: control of barrier function and regulation in response to oxidant stress.Antioxidants & redox signaling · 2011
    Review
16. Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function.American journal of physiology. Lung cellular and molecular physiology · 2011
    Article
17. Specificity of interaction between clostridium perfringens enterotoxin and claudin-family tight junction proteins.Toxins · 2010
    Review

Corrections and comments

• Comment on
  Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury.2009

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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