ArticleJournal of bacteriology2009
Identification and characterization of gshA, a gene encoding the glutamate-cysteine ligase in the halophilic archaeon Haloferax volcanii.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Microbially derived glutathione from Eubacterium rectale alleviates oxidative stress and promotes intestinal epithelial recovery.Microbiome · 2026Article
- Glutathione Is Involved in the Reduction of Methylarsenate to Generate Antibiotic Methylarsenite in Enterobacter sp. Strain CZ-1.Applied and environmental microbiology · 2022Article
- The multi-drug efflux system AcrABZ-TolC is essential for infection ofJournal of virology · 2021Article
- Article
- Redox and Thiols in Archaea.Antioxidants (Basel, Switzerland) · 2020Review
- Transcriptomes of the Extremely Thermoacidophilic Archaeon Metallosphaera sedula Exposed to Metal "Shock" Reveal Generic and Specific Metal Responses.Applied and environmental microbiology · 2016Article
- The methylaspartate cycle in haloarchaea and its possible role in carbon metabolism.The ISME journal · 2016Article
- Dynamic Metabolite Profiling in an Archaeon Connects Transcriptional Regulation to Metabolic Consequences.PloS one · 2015Article
- Synthesis of silver nanoparticles using haloarchaeal isolate Halococcus salifodinae BK3.Extremophiles : life under extreme conditions · 2013Article
- Mechanisms of metal resistance and homeostasis in haloarchaea.Archaea (Vancouver, B.C.) · 2013Review
- Metallochaperones regulate intracellular copper levels.PLoS computational biology · 2013Article
- The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases.Biochemistry · 2011Article
- Novel insights into the diversity of catabolic metabolism from ten haloarchaeal genomes.PloS one · 2011Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Halophilic archaea were found to contain in their cytoplasm millimolar concentrations of gamma-glutamylcysteine (gamma GC) instead of glutathione. Previous analysis of the genome sequence of the archaeon Halobacterium sp. strain NRC-1 has indicated the presence of a sequence homologous to sequences known to encode the glutamate-cysteine ligase GshA. We report here the identification of the gshA gene in the extremely halophilic archaeon Haloferax volcanii and show that H. volcanii gshA directs in vivo the synthesis and accumulation of gamma GC. We also show that the H. volcanii gene when expressed in an Escherichia coli strain lacking functional GshA is able to restore synthesis of glutathione.
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