ArticleJournal of bacteriology2009
The dual-functioning fumarate reductase is the sole succinate:quinone reductase in Campylobacter jejuni and is required for full host colonization.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 69 citations in OpenAlex.
- Poultry handling-related stress alters membrane composition, extracellular vesicle production, survival, and virulence inApplied and environmental microbiology · 2026Article
- Proteomic characterization ofFrontiers in microbiology · 2026Article
- Structural basis of menaquinone reduction by succinate dehydrogenase from Chloroflexus aurantiacus.Nature communications · 2025Article
- Multi-Omics ofMicroorganisms · 2024Article
- Substrate Utilisation and Energy Metabolism in Non-GrowingMicroorganisms · 2022Article
- Inter-Relationship Between a Transcriptional Regulator of Flagella GenesBioMed research international · 2022Article
- Membrane Proteocomplexome ofFrontiers in microbiology · 2020Article
- Analyses of energy metabolism and stress defence provide insights intoGut pathogens · 2020Article
- Binding of Phage-Encoded FlaGrab to MotileFrontiers in microbiology · 2020Article
- In Vivo Proteome of Pseudomonas aeruginosa in Airways of Cystic Fibrosis Patients.Journal of proteome research · 2019Article
- Proteomics Reveals Multiple Phenotypes Associated withMolecular & cellular proteomics : MCP · 2019Article
- Regulation of Respiratory Pathways in Campylobacterota: A Review.Frontiers in microbiology · 2019Review
- Interaction of Copper Toxicity and Oxidative Stress in Campylobacter jejuni.Journal of bacteriology · 2018Article
- Bacterial periplasmic nitrate and trimethylamine-N-oxide respiration coupled to menaquinol-cytochrome c reductase (Qcr): Implications for electrogenic reduction of alternative electron acceptors.Scientific reports · 2018Article
- Site-directed mutagenesis of Campylobacter concisus respiratory genes provides insight into the pathogen's growth requirements.Scientific reports · 2018Article
- Transcriptome and proteome dynamics in chemostat culture reveal how Campylobacter jejuni modulates metabolism, stress responses and virulence factors upon changes in oxygen availability.Environmental microbiology · 2017Article
- Article
- Analysis of Campylobacter jejuni infection in the gnotobiotic piglet and genome-wide identification of bacterial factors required for infection.Scientific reports · 2017Article
- Editorial: About the Foodborne PathogenFrontiers in microbiology · 2017Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter jejuni encodes all the enzymes necessary for a complete oxidative tricarboxylic acid (TCA) cycle. Because of its inability to utilize glucose, C. jejuni relies exclusively on amino acids as the source of reduced carbon, and they are incorporated into central carbon metabolism. The oxidation of succinate to fumarate is a key step in the oxidative TCA cycle. C. jejuni encodes enzymes annotated as a fumarate reductase (Cj0408 to Cj0410) and a succinate dehydrogenase (Cj0437 to Cj0439). Null alleles in the genes encoding each enzyme were constructed. Both enzymes contributed to the total fumarate reductase activity in vitro. The frdA::cat(+) strain was completely deficient in succinate dehydrogenase activity in vitro and was unable to perform whole-cell succinate-dependent respiration. The sdhA::cat(+) strain exhibited wild-type levels of succinate dehydrogenase activity both in vivo and in vitro. These data indicate that Frd is the only succinate dehydrogenase in C. jejuni and that the protein annotated as a succinate dehydrogenase has been misannotated. The frdA::cat(+) strain was also unable to grow with the characteristic wild-type biphasic growth pattern and exhibited only the first growth phase, which is marked by the consumption of aspartate, serine, and associated organic acids. Substrates consumed in the second growth phase (glutamate, proline, and associated organic acids) were not catabolized by the the frdA::cat(+) strain, indicating that the oxidation of succinate is a crucial step in metabolism of these substrates. Chicken colonization trials confirmed the in vivo importance of succinate oxidation, as the frdA::cat(+) strain colonized chickens at significantly lower levels than the wild type, while the sdhA::cat(+) strain colonized chickens at wild-type levels.
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Registered trials
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