ArticlePlant physiology2009
Resistance to the Pseudomonas syringae effector HopA1 is governed by the TIR-NBS-LRR protein RPS6 and is enhanced by mutations in SRFR1.
Article in Plant physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59 citing papers in PubMed, 127 citations in OpenAlex.
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- Fine mapping and identification of the downy mildew resistance gene BoDMR2 in Cabbage (Brassica oleracea L. var. capitata).BMC plant biology · 2024Article
- Constitutive Overexpression of an NB-ARC Gene from Wild ChineseInternational journal of molecular sciences · 2024Article
- Transcriptome Analysis of Sweet Cherry (Plants (Basel, Switzerland) · 2023Article
- Rootstock-induced scion resistance against tobacco mosaic virus is associated with the induction of defence-related transcripts and graft-transmissible mRNAs.Molecular plant pathology · 2023Article
- Chromosome-scale genome assembly ofHorticulture research · 2023Article
- Genome-wide association studies reveal novel loci for resistance to groundnut rosette disease in the African core groundnut collection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Phased grapevine genome sequence of anFrontiers in plant science · 2023Article
- Engineering plant immune circuit: walking to the bright future with a novel toolbox.Plant biotechnology journal · 2023Review
- Genome-wide polymorphism and genic selection in feral and domesticated lineages of Cannabis sativa.G3 (Bethesda, Md.) · 2022Article
- Alternative splicing as a key player in the fine-tuning of the immunity response in Arabidopsis.Molecular plant pathology · 2022Review
- Pathogen effectors: What do they do at plasmodesmata?Molecular plant pathology · 2022Review
- Thirty years of resistance: Zig-zag through the plant immune system.The Plant cell · 2022Review
- Genomes shed light on the evolution of Begonia, a mega-diverse genus.The New phytologist · 2022Article
- A phytobacterial TIR domain effector manipulates NADThe New phytologist · 2022Article
- TIR signal promotes interactions between lipase-like proteins and ADR1-L1 receptor and ADR1-L1 oligomerization.Plant physiology · 2021Article
- Inheritance of Black Rot Resistance and Development of Molecular Marker Linked toPlants (Basel, Switzerland) · 2021Article
- Metatranscriptomic Comparison of Endophytic and PathogenicMolecular plant-microbe interactions : MPMI · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Pseudomonas syringae-Arabidopsis (Arabidopsis thaliana) interaction is an extensively studied plant-pathogen system. Arabidopsis possesses approximately 150 putative resistance genes encoding nucleotide binding site (NBS) and leucine-rich repeat (LRR) domain-containing proteins. The majority of these belong to the Toll/Interleukin-1 receptor (TIR)-NBS-LRR (TNL) class. Comparative studies with the coiled-coil-NBS-LRR genes RPS2, RPM1, and RPS5 and isogenic P. syringae strains expressing single corresponding avirulence genes have been particularly fruitful in dissecting specific and common resistance signaling components. However, the major TNL class is represented by a single known P. syringae resistance gene, RPS4. We previously identified hopA1 from P. syringae pv syringae strain 61 as an avirulence gene that signals through ENHANCED DISEASE SUSCEPTIBILITY1, indicating that the corresponding resistance gene RPS6 belongs to the TNL class. Here we report the identification of RPS6 based on a forward-genetic screen and map-based cloning. Among resistance proteins of known function, the deduced amino acid sequence of RPS6 shows highest similarity to the TNL resistance protein RAC1 that determines resistance to the oomycete pathogen Albugo candida. Similar to RPS4 and other TNL genes, RPS6 generates alternatively spliced transcripts, although the alternative transcript structures are RPS6 specific. We previously characterized SRFR1 as a negative regulator of avrRps4-triggered immunity. Interestingly, mutations in SRFR1 also enhanced HopA1-triggered immunity in rps6 mutants. In conclusion, the cloning of RPS6 and comparisons with RPS4 will contribute to a closer dissection of the TNL resistance pathway in Arabidopsis.
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