ReviewChemical senses2009
Molecular tuning of odorant receptors and its implication for odor signal processing.
Review in Chemical senses, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Divergent Evolutionary Pressures Shape Olfactory Sensitivity of the Maxillary Palps in Tephritidae Fruit Flies.Ecology and evolution · 2025Article
- Deciphering olfactory receptor binding mechanisms: a structural and dynamic perspective on olfactory receptors.Frontiers in molecular biosciences · 2024Review
- Characterization of human oxidoreductases involved in aldehyde odorant metabolism.Scientific reports · 2023Article
- Distinct sets of olfactory receptors highly expressed in different human tissues evaluated by meta-transcriptome analysis: Association of OR10A6 in skin with keratinization.Frontiers in cell and developmental biology · 2023Article
- Primacy coding facilitates effective odor discrimination when receptor sensitivities are tuned.PLoS computational biology · 2019Article
- Identification of Chinese Herbal Medicines with Electronic Nose Technology: Applications and Challenges.Sensors (Basel, Switzerland) · 2017Review
- Receptor arrays optimized for natural odor statistics.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The state of the art of odorant receptor deorphanization: a report from the orphanage.The Journal of general physiology · 2014Review
- Computational reverse chemical ecology: virtual screening and predicting behaviorally active semiochemicals for Bactrocera dorsalis.BMC genomics · 2014Article
- Genome-wide Membrane Protein Structure Prediction.Current genomics · 2013Article
- Early olfactory processing in Drosophila: mechanisms and principles.Annual review of neuroscience · 2013Review
- Pharmacology of mammalian olfactory receptors.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Modeling of mammalian olfactory receptors and docking of odorants.Biophysical reviews · 2012Review
- Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity.ACS chemical biology · 2012Article
- Article
- Perspectives on: information and coding in mammalian sensory physiology: response kinetics of olfactory receptor neurons and the implications in olfactory coding.The Journal of general physiology · 2011Article
- Temporal coding of odor mixtures in an olfactory receptor neuron.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Origin of basal activity in mammalian olfactory receptor neurons.The Journal of general physiology · 2010Article
- Achieving singularity in mammalian odorant receptor gene choice.Chemical senses · 2010Review
- Molecular components of signal amplification in olfactory sensory cilia.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The discovery of the odorant receptor (OR) family by Buck and Axel in 1991 provided a quantum jump in our understanding of olfactory function. However, the study of the responsiveness of ORs to odor ligands was challenging due to the difficulties in deorphanizing the receptors. In this manuscript, we review recent findings of OR responsiveness that have come about through improved OR deorphanization methods, site-directed mutagenesis, structural modeling studies, and studies of OR responses in situ in olfactory sensory neurons. Although there has been a major leap in our understanding of receptor-ligand interactions and how these contribute to the input to the olfactory system, an improvement of our understanding of receptor structure and dynamics and interactions with intracellular and extracellular proteins is necessary.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.