Evidence map›Paper›PMID 19524518›Full record

ArticleNeuron2009

Synaptobrevin, sphingolipids, and secretion: lube 'n' go at the synapse.

Matthijs Verhage, Gerrit van Meer

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Matthijs VerhageDepartment of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit, VU Medical Center, De Boelelaan 1085, 1081HV Amsterdam, The Netherlands. matthijs.verhage@cncr.vu.nl
Gerrit van Meer
Amsterdam Neuroscience · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For neurotransmitter release to occur, proteins and lipids have to work together. The classical view of this process is that a variety of proteins work hard to force the unwilling, fusion-aversive lipids into merging. In this issue of Neuron, a study by Darios et al. paints the opposite picture: a lipid metabolite stimulates the reluctant vSNARE synaptobrevin to engage in fusogenic protein complexes.

Indexed as

AnimalsR-SNARE ProteinsSecretinSphingolipidsSynapsesR-SNARE ProteinsSecretinSphingolipids

Identifiers

PMID19524518
OpenAlexW2140040276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.