ArticleAmerican journal of preventive medicine2009
Effects of body size and body fatness on left ventricular mass in children and adolescents: Project HeartBeat!
Article in American journal of preventive medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-alcoholic fatty liver disease association with structural heart, systolic and diastolic dysfunction: a meta-analysis.Hepatology international · 2022Pooled it
- Left ventricular mass in newborn with perinatal asphxia: Assessment of allometric relations and impact of birth weight.World journal of clinical cases · 2026Article
- Analysis of left ventricular mass for African American individuals using multi-ancestry polygenic risk scores: the Jackson Heart Study.Open heart · 2025Article
- Cardiac Complications Associated with Eating Disorders in Children: A Multicenter Retrospective Study.Pediatric gastroenterology, hepatology & nutrition · 2022Article
- Associations of Maternal Glycemia in the First Half of Pregnancy With Alterations in Cardiac Structure and Function in Childhood.Diabetes care · 2020Observational
- Scaling left ventricular mass in adolescent female soccer players.BMC pediatrics · 2020Article
- Impact of Obesity on Left Ventricular Thickness in Children with Hypertrophic Cardiomyopathy.Pediatric cardiology · 2019Article
- Left ventricular mass is underestimated in overweight children because of incorrect body size variable chosen for normalization.PloS one · 2019Article
- The Prevalence of Left Ventricular Hypertrophy in Obese Children Varies Depending on the Method Utilized to Determine Left Ventricular Mass.Pediatric cardiology · 2016Article
- Risk profiles of lipids, blood pressure, and anthropometric measures in childhood and adolescence: project heartBeat!BMC obesity · 2016Article
- Effects of Curtailed Juvenile State on Cardiac Structure and Function in Adulthood: The Fels Longitudinal Study.Journal of childhood obesity · 2016Article
- Impact of childhood obesity on cardiac structure and function.Current treatment options in cardiovascular medicine · 2014Article
- Cardiovascular Risk Factors from Early Life Predict Future Adult Cardiac Structural and Functional Abnormalities: A Systematic Review of the Published Literature.Journal of cardiology and therapeutics · 2014Article
- Factors influencing left ventricular hypertrophy in children and adolescents with or without family history of premature myocardial infarction.Advanced biomedical research · 2014Article
- The effect of feto-maternal size and childhood growth on left ventricular mass and arterial stiffness in Afro-Caribbean children.Journal of human hypertension · 2011Article
- Prevalence of overweight and obesity in young adults in Uganda.African health sciences · 2010Article
- Project HeartBeat! Concept, development, and design.American journal of preventive medicine · 2009Article
- Normal reference ranges for the left ventricular mass and left ventricular mass index in preterm infants.Annals of pediatric cardiologyArticle
- Determinants of Left Ventricular Mass Among Apparently Normal Children in Enugu State.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
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4 authors.
Funding
Abstract
backgroundLeft ventricular mass (LVM) is a strong predictor of cardiovascular disease in adults. Available study findings on effects of body fatness on LVM in children are inconsistent. Understanding the impact of body fat on LVM in children may help prevent excessive LVM through measures to reduce overweight and obesity.
methodsHealthy children (n=678) aged 8, 11, and 14 years at baseline were examined at 4-month intervals for up to 4 years (1991-1995); 4608 valid measurements of LVM were obtained with M-mode echocardiography. A multilevel linear model was used for analysis. The impact of body size was examined by adding separately nine body-size indicators to a basic LVM-gender-age model. The impact of body fatness was tested by introducing four body-fatness indicators into the nine models, yielding 36 models.
resultsAll body-size indicators showed strong, positive effects on LVM. In models containing weight or body surface area (measuring both fat-free and fat contributions to body size), additional effects of body fatness were negative; in models containing fat-free mass (FFM) or height (both measuring body size independent of body fat), increased body fatness was related to a significant increase in LVM. For example, in models with FFM as a body-size indicator, a 1-SD increase in percent body fat or fat mass was related to a 5.4- or 7.2-g increase in LVM, respectively.
conclusionsEffects of body size on LVM attributable to fat-free body mass can be distinguished from those attributable to fat body mass; both are independent, positive predictors, but the former is the stronger determinant. When a body-size indicator not independent of body fat is used as a predictor, effects of fat-free body mass and fat body mass are forced to relate to the same indicator; because their magnitudes are estimated to be equal, the effect of fat body mass is overestimated. Thus, when an additional body-fatness indicator is included in the prediction of LVM, the additional estimated effect related to the indicator appears to be negative.
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