ArticleAmerican journal of preventive medicine2009
Effects of apolipoprotein E genotype on blood cholesterol in adolescent girls.
Article in American journal of preventive medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Genetic variants of APOE and CCR4 as determinants of myocardial infarction among type 2 diabetes patients: a South Indian case-control analysis.Molecular biology reports · 2026Article
- APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PMBiomolecules · 2023Review
- Change and Stability in Sibling Resemblance in Obesity Markers: The Portuguese Sibling Study on Growth, Fitness, Lifestyle, and Health.Journal of obesity · 2019Article
- Impact of Apo E gene polymorphism on HCV therapy related outcome in a cohort of HCV Egyptian patients.Journal, genetic engineering & biotechnology · 2018Review
- Risk profiles of lipids, blood pressure, and anthropometric measures in childhood and adolescence: project heartBeat!BMC obesity · 2016Article
- The apolipoprotein E gene and Taq1A polymorphisms in childhood obesity.Genetic testing and molecular biomarkers · 2010Article
- Findings from Project HeartBeat! Their importance for CVD prevention.American journal of preventive medicine · 2009Article
- Project HeartBeat! Concept, development, and design.American journal of preventive medicine · 2009Article
- Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients - A Preliminary Case-Controlled Study.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundFew investigations have examined whether associations between the apolipoprotein E genotype (apo E) and total cholesterol or LDL-C are modified or explained by other characteristics. The objective of this study was to explore effects of behavioral characteristics, physical growth, body composition, sexual maturation, and endocrine function on age trajectories of total cholesterol and LDL-C by apo E in adolescent girls.
methodsParticipants were 247 Caucasian adolescent girls followed for 4 years. Apo E genotyping and plasma lipid concentrations were determined from fasting blood samples using standard enzymatic methods. Age; gender; fat-free mass (FFM); BMI; percent body fat (PBF); sexual maturation (pubic hair, Tanner Stages 1-5); estradiol concentration (EST); energy intake; and physical activity were collected or calculated with standard methods.
resultsIn models including the proposed explanatory variables, apo E genotype remained strongly associated with total cholesterol and LDL-C. Girls with the epsilon (epsilon)3/3 and epsilon3/4 genotypes (where epsilon is the protein isoform of the apo E gene), relative to those with epsilon2/3, had total cholesterol and LDL-C values 16-23 mg/dL higher throughout adolescence. Age-apo E interaction terms remained significant. FFM, BMI, PBF, pubic-hair stage, and EST showed a significant effect on total cholesterol and LDL-C. When the combination of pubic-hair stage, EST, and one of FFM, BMI, and PBF was included in total cholesterol or LDL-C models, only EST was significant.
conclusionsAdolescent girls with epsilon3/3 and epsilon3/4 genotypes had higher total cholesterol and LDL-C and showed different patterns of change, compared to those with epsilon2/3 genotype. These apo E effects were independent of behavioral characteristics, physical growth, body composition, sexual maturation, and endocrine function. Girls with epsilon3/3 or epsilon3/4 genotypes may be at risk for elevated total cholesterol and LDL-C later in life.
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