ArticleThe Journal of steroid biochemistry and molecular biology2009
High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice.
Article in The Journal of steroid biochemistry and molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing.Nature microbiology · 2026Article
- Sex steroid hormone synthesis, metabolism, and the effects on the mammalian olfactory system.Cell and tissue research · 2023Review
- Differences in peripheral sensory input to the olfactory bulb between male and female mice.Scientific reports · 2017Article
- Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model.Drug metabolism and disposition: the biological fate of chemicals · 2013Article
- Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.Drug metabolism and disposition: the biological fate of chemicals · 2012Article
- A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.Molecular pharmacology · 2011Article
- Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.The Journal of pharmacology and experimental therapeutics · 2010Article
- Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.The Journal of pharmacology and experimental therapeutics · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
To better understand androgen function in the mammalian nose, we have determined the levels of testosterone (T) in the olfactory mucosa (OM, which harbors the olfactory receptor neurons) and the lateral nasal gland (LNG, which is the largest anterior nasal gland) of C57BL/6 mice. The results indicated that, in adult male mice, T levels in the LNG were substantially higher than those in the OM and other non-reproductive or non-endocrine tissues examined, including liver, kidney, and brain. Furthermore, in the LNG, the high T levels were accompanied by high levels of salivary androgen-binding protein (sABP) and low microsomal T-hydroxylase activities. The high abundance of T and sABP in the LNG suggests not only that the LNG is a storage site for androgen, but also the possibility that unusually high T levels may occur in other organs that have abundant expression of sABP but low expression of steroid-metabolizing enzymes. Our findings suggest a critical need to determine androgen levels in various organs, as well as to establish the functional significance of an unusually high T level in the LNG, a gland known for its secretion of biologically active molecules, such as odorant binding proteins and immunoglobulin A, to the nasal cavity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.