ArticleInternational journal of pharmaceutics2009
Nanoparticles engineered from lecithin-in-water emulsions as a potential delivery system for docetaxel.
Article in International journal of pharmaceutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 96 citations in OpenAlex.
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- Sterols are key to coral larvae survival, swimming capacity, and thermal tolerance.Communications biology · 2025Article
- Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution.Cell reports · 2024Article
- Cubic nanoparticles as potential carriers for a natural anticancer drug: development, in vitro and in vivo characterization.Drug delivery and translational research · 2023Article
- Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1.Bioactive materials · 2023Article
- Ion exchange column technique as a novel method for evaluating the release of docetaxel from different lipid nanoparticles.Drug delivery and translational research · 2022Article
- Metformin-loaded lecithin nanoparticles induce colorectal cancer cytotoxicity via epigenetic modulation of noncoding RNAs.Molecular biology reports · 2021Article
- Docetaxel-Loaded Poly(3HB-Nanomaterials (Basel, Switzerland) · 2020Article
- Article
- ArtinM Grafted Phospholipid Nanoparticles for Enhancing Antibiotic Cellular Uptake Against Intracellular Infection.International journal of nanomedicine · 2020Article
- Identification and evaluation of novel drug combinations of Aurora kinase inhibitor CCT137690 for enhanced efficacy in oral cancer cells.Cell cycle (Georgetown, Tex.) · 2019Article
- ComparativeToxicological research · 2019Article
- Cellular uptake and cytotoxicity studies of pH-responsive polymeric nanoparticles fabricated by dispersion polymerization.Journal of nanoscience and nanomedicine · 2018Article
- Ceramide lipid-based nanosuspension for enhanced delivery of docetaxel with synergistic antitumor efficiency.Drug delivery · 2017Article
- Lipid peroxidation: Its effects on the formulation and use of pharmaceutical emulsions.Asian journal of pharmaceutical sciences · 2017Review
- In vitro and in vivo evaluation of docetaxel-loaded stearic acid-modified Bletilla striata polysaccharide copolymer micelles.PloS one · 2017Article
- Docetaxel-Loaded Self-Assembly Stearic Acid-Modified Bletilla striata Polysaccharide Micelles and Their Anticancer Effect: Preparation, Characterization, Cellular Uptake and In Vitro Evaluation.Molecules (Basel, Switzerland) · 2016Article
- Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin.Scientific reports · 2016Article
- New Oral Formulation and in Vitro Evaluation of Docetaxel-Loaded Nanomicelles.Molecules (Basel, Switzerland) · 2016Article
- Development and characterization of self-assembling lecithin-based mixed polymeric micelles containing quercetin in cancer treatment and an in vivo pharmacokinetic study.International journal of nanomedicine · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Docetaxel is a potent anticancer drug. However, there continues to be a need for alternative docetaxel delivery systems to improve its efficacy. We reported the engineering of a novel spherical nanoparticle formulation ( approximately 270 nm) from lecithin-in-water emulsions. Docetaxel can be incorporated into the nanoparticles, and the resultant docetaxel-nanoparticles were stable when stored as an aqueous suspension. The release of the docetaxel from the nanoparticles was likely caused by a combination of diffusion and Case II transport. The docetaxel-in-nanoparticles were more effective in killing tumor cells in culture than free docetaxel. Moreover, the docetaxel-nanoparticles did not cause any significant red blood cell lysis or platelet aggregation in vitro, nor did they induce detectable acute liver damage when injected intravenously into mice. Finally, compared to free docetaxel, the intravenously injected docetaxel-nanoparticles increased the accumulation of the docetaxel in a model tumor in mice by 4.5-fold. These lecithin-based nanoparticles have the potential to be a novel biocompatible and efficacious delivery system for docetaxel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.