ArticleStructure (London, England : 1993)2009
The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit.
Article in Structure (London, England : 1993), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed, 71 citations in OpenAlex.
- Viral Genomic DNA Packaging Machinery.Sub-cellular biochemistry · 2024Review
- Molecular Architecture of Salmonella Typhimurium Virus P22 Genome Ejection Machinery.Journal of molecular biology · 2023Article
- Review
- Structural insights into a spindle-shaped archaeal virus with a sevenfold symmetrical tail.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cryo-EM Structure of a Kinetically Trapped Dodecameric Portal Protein from the Pseudomonas-phage PaP3.Journal of molecular biology · 2022Article
- Single-particle virology.Biophysical reviews · 2020Review
- Structure and genome ejection mechanism ofScience advances · 2019Article
- Time-resolved DNA release from an O-antigen-specificThe Journal of biological chemistry · 2019Article
- Protein cage assembly across multiple length scales.Chemical Society reviews · 2018Review
- Review
- High-resolution structure of podovirus tail adaptor suggests repositioning of an octad motif that mediates the sequential tail assembly.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Discovery of an expansive bacteriophage family that includes the most abundant viruses from the human gut.Nature microbiology · 2018Article
- Tail tubular protein A: a dual-function tail protein of Klebsiella pneumoniae bacteriophage KP32.Scientific reports · 2017Article
- Portal protein functions akin to a DNA-sensor that couples genome-packaging to icosahedral capsid maturation.Nature communications · 2017Article
- Article
- Acquiring Structural Information on Virus Particles with Charge Detection Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Article
- Structural Plasticity of the Protein Plug That Traps Newly Packaged Genomes in Podoviridae Virions.The Journal of biological chemistry · 2016Article
- Structure of a Bacterial Virus DNA-Injection Protein Complex Reveals a Decameric Assembly with a Constricted Molecular Channel.PloS one · 2016Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The portal channel is a key component in the life cycle of bacteriophages and herpesviruses. The bacteriophage P22 portal is a 1 megadalton dodecameric oligomer of gp1 that plays key roles in capsid assembly, DNA packaging, assembly of the infection machinery, and DNA ejection. The portal is the nucleation site for the assembly of 39 additional subunits generated from multiple copies of four gene products (gp4, gp10, gp9, and gp26), which together form the multifunctional tail machine. These components are organized with a combination of 12-fold (gp1, gp4), 6-fold (gp10, trimers of gp9), and 3-fold (gp26, gp9) symmetry. Here we present the 3-dimensional structures of the P22 assembly-naive portal formed from expressed subunits (gp1) and the intact tail machine purified from infectious virions. The assembly-naive portal structure exhibits a striking structural similarity to the structures of the portal proteins of SPP1 and phi29 derived from X-ray crystallography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.