ReviewDevelopmental biology2010
The gene regulatory network basis of the "community effect," and analysis of a sea urchin embryo example.
Review in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed.
- Keeping up with the neighbours: local synchronisation of cell fate decisions during development.EMBO reports · 2026Review
- An RNA interference approach for functional studies in the sea urchin and its use in analysis of nodal signaling gradients.Developmental biology · 2024Article
- Combinatorial regulatory states define cell fate diversity during embryogenesis.Nature communications · 2024Article
- An RNA interference approach for functional studies in the sea urchin and its use in analysis of Nodal signaling gradients.bioRxiv : the preprint server for biology · 2024Article
- Population-level antagonism between FGF and BMP signaling steers mesoderm differentiation in embryonic stem cells.Biology open · 2023Article
- Development of a larval nervous system in the sea urchin.Current topics in developmental biology · 2022Review
- Segmentation and patterning of the vertebrate hindbrain.Development (Cambridge, England) · 2021Review
- Causal Gene Regulatory Network Modeling and Genomics: Second-Generation Challenges.Journal of computational biology : a journal of computational molecular cell biology · 2019Article
- Self-organization of stem cells into embryos: A window on early mammalian development.Science (New York, N.Y.) · 2019Article
- Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain.Developmental cell · 2018Article
- Modeling Mammalian Gastrulation With Embryonic Stem Cells.Current topics in developmental biology · 2018Review
- Assessing regulatory information in developmental gene regulatory networks.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Comparative Study of Regulatory Circuits in Two Sea Urchin Species Reveals Tight Control of Timing and High Conservation of Expression Dynamics.PLoS genetics · 2015Article
- Ectopic hbox12 Expression Evoked by Histone Deacetylase Inhibition Disrupts Axial Specification of the Sea Urchin Embryo.PloS one · 2015Article
- Early asymmetric cues triggering the dorsal/ventral gene regulatory network of the sea urchin embryo.eLife · 2014Article
- Specific functions of the Wnt signaling system in gene regulatory networks throughout the early sea urchin embryo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Genome-Wide Mapping of Chromatin State of Mouse Forelimbs.Open access bioinformatics · 2014Article
- Oral-aboral axis specification in the sea urchin embryo, IV: hypoxia radializes embryos by preventing the initial spatialization of nodal activity.Developmental biology · 2014Article
- New regulatory circuit controlling spatial and temporal gene expression in the sea urchin embryo oral ectoderm GRN.Developmental biology · 2013Article
- Dpp-induced Egfr signaling triggers postembryonic wing development in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The "Community Effect" denotes intra-territorial signaling amongst cells which constitute a particular tissue or embryonic progenitor field. The cells of the territory express the same transcriptional regulatory state, and the intra-territorial signaling is essential to maintenance of this specific regulatory state. The structure of the underlying gene regulatory network (GRN) subcircuitry explains the genomically wired mechanism by which community effect signaling is linked to the continuing transcriptional generation of the territorial regulatory state. A clear example is afforded by the oral ectoderm GRN of the sea urchin embryo where cis-regulatory evidence, experimental embryology, and network analysis combine to provide a complete picture. We review this example and consider less well known but similar cases in other developing systems where the same subcircuit GRN topology is present. To resolve mechanistic issues that arise in considering how community effect signaling could operate to produce its observed effects, we construct and analyze the behavior of a quantitative model of community effect signaling in the sea urchin embryo oral ectoderm. Community effect network topology could constitute part of the genomic regulatory code that defines transcriptional function in multicellular tissues composed of cells in contact, and hence may have arisen as a metazoan developmental strategy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.